Evidence map›Paper›PMID 39917061›Full record

ArticleFrontiers in medicine2025

Navigating the potential and pitfalls of large language models in patient-centered medication guidance and self-decision support.

Serhat Aydin, Mert Karabacak, Victoria Vlachos, Konstantinos Margetis

Abstract read
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Large Language Model Responses to Common Otolaryngological Questions: Evaluating Accuracy, Appropriateness, Readability, and Hallucinations.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
    Observational
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Assessing Patient Education Materials for Colorectal Cancer Generated by Four Large Language Models: Readability, Quality, and Transparency Challenges.Journal of cancer education : the official journal of the American Association for Cancer Education · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Serhat AydinSchool of Medicine, Koç University, Istanbul, Türkiye.
Mert KarabacakDepartment of Neurosurgery, Mount Sinai Health System, New York, NY, United States.
Victoria VlachosCollege of Human Ecology, Cornell University, Ithaca, NY, United States.
Konstantinos MargetisDepartment of Neurosurgery, Mount Sinai Health System, New York, NY, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Large Language Models (LLMs) are transforming patient education in medication management by providing accessible information to support healthcare decision-making. Building on our recent scoping review of LLMs in patient education, this perspective examines their specific role in medication guidance. These artificial intelligence (AI)-driven tools can generate comprehensive responses about drug interactions, side effects, and emergency care protocols, potentially enhancing patient autonomy in medication decisions. However, significant challenges exist, including the risk of misinformation and the complexity of providing accurate drug information without access to individual patient data. Safety concerns are particularly acute when patients rely solely on AI-generated advice for self-medication decisions. This perspective analyzes current capabilities, examines critical limitations, and raises questions regarding the possible integration of LLMs in medication guidance. We emphasize the need for regulatory oversight to ensure these tools serve as supplements to, rather than replacements for, professional healthcare guidance.

Indexed as

artificial intelligenceChatGPTdeep learningLarge Language Modelsmachine learningpatient educationself-medication

Identifiers

PMID39917061
PMCPMC11798948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.