Evidence map›Paper›PMID 39916981›Full record

ArticleFrontiers in molecular neuroscience2024

Impact of modulating leptin sensitivity on the transcriptomic profile of adult-derived hypothalamic mouse neurons.

Ewa Ocłoń, Artur Gurgul, Tomasz Szmatoła, Igor Jasielczuk, Miroslaw Kucharski, Joanna Zubel-Łojek, Dorota Anna Zieba

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ewa OcłońLaboratory of Recombinant Proteins Production, University of Agriculture in Krakow, Krakow, Poland.
Artur GurgulDepartment of Basic Sciences, University of Agriculture in Krakow, Krakow, Poland.
Tomasz SzmatołaDepartment of Basic Sciences, University of Agriculture in Krakow, Krakow, Poland.
Igor JasielczukDepartment of Basic Sciences, University of Agriculture in Krakow, Krakow, Poland.
Miroslaw KucharskiDepartment of Animal Physiology and Endocrinology, University of Agriculture in Krakow, Krakow, Poland.
Joanna Zubel-ŁojekDepartment of Animal Physiology and Endocrinology, University of Agriculture in Krakow, Krakow, Poland.
Dorota Anna ZiebaDepartment of Animal Biotechnology, University of Agriculture in Krakow, Krakow, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The modulation of leptin sensitivity in hypothalamic neurons plays a crucial role in metabolic regulation and the development of obesity. Three distinct approaches, exposure to leptin (LEPA), administration of leptin antagonist (LANTA), and treatment with palmitate (PA), were explored in this study to assess their effects on adult-derived mHypoA-2/12 neurons and the resulting transcriptomic signatures. To this end, 3' mRNA-Seq transcriptome analysis was employed, unexpectedly revealing downregulation of key genes associated with the NOD-like receptor signaling pathway (

Indexed as

hypothalamic neuronsinflammationIRF9leptinleptin resistancepalmitic acidRNA-seq and Traf5the C-type lectin receptor signaling pathway (Nfkb2)

Identifiers

PMID39916981
PMCPMC11800294

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.