Evidence map›Paper›PMID 39916965›Full record

ArticleFrontiers in veterinary science2024

The relationship between deltamethrin-induced behavioral changes and acetylcholinesterase activity in zebrafish embryos or larvae based on transcriptome.

Chunyu Liu, Yantong Guo, Xue Zhang, Hongsong Chen, Maomao Han, Han Wang, Jieyao Niu, Jinfei He, Jingfeng Yang, Wu Dong and 1 more

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In one paragraph

Article in Frontiers in veterinary science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Chunyu LiuCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, China.
Yantong GuoCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, China.
Xue ZhangCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, China.
Hongsong ChenCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, China.
Maomao HanCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, China.
Han WangCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, China.
Jieyao NiuCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, China.
Jinfei HeCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, China.
Jingfeng YangCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, China.
Wu DongCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, China.
Jiangdong XueCollege of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Deltamethrin (DM) is a broad-spectrum insecticide that is widely used to control agricultural pests. Recently, DM has posed a potential threat to the health of infants and young children, and this is because of the environmental and food pollution that is caused by the extensive use of DM. Methods: In this study, zebrafish ( Results: The results showed that DM caused an increase in coiling movement, heart rate, and apoptosis in the brain in early zebrafish embryos or larvae. It also caused a decrease in the expression of acetylcholinesterase-associated genes and the activity of acetylcholinesterase, which also led to an increase in the acetylcholinesterase content. The transcriptome data also showed that low concentration DM induced acetylcholine-related gene signaling pathways. The above results suggest that low doses of DM may induce neurodegeneration because DM exposure inhibits acetylcholinesterase, leading to brain cell apoptosis and behavioral changes in the zebrafish embryos or larvae. Micro-injection of zebrafish embryos at the 2-4 cell stage knocked down or overexpressed the acetylcholinesterase gene showed that the behavior and enzyme activity of zebrafish had some effects. Conclusion: This study explored the relationship between acetylcholinesterase and the change in zebrafish behavior caused by DM exposure to provide a basis for the treatment of DM poisoning in the aquaculture.

Indexed as

acetylcholinesterasebehavioral changesdeltamethrinneurotoxicityzebrafish embryos

Identifiers

PMID39916965
PMCPMC11799562

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.