Evidence map›Paper›PMID 39916945›Full record

ArticleFrontiers in neurology2025

The impact of endolymphatic hydrops on wideband acoustic immittance and otoacoustic emissions in guinea pigs.

Huan Lin, Xuanyi Li, Huiying Zhang, Yi Mu, Xi Wang, Naveena Konduru, Renlong Ji, Wen Liu, Zhao Fei, Wen Jiang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Huan Lin *Jiangsu Auditory Engineering Research Center, The Second College of Clinical Medicine, Xuzhou Medical University, Xuzhou, China.
Xuanyi Li *ENT Department, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Huiying ZhangThe First College of Clinical Medicine, Xuzhou Medical University, Xuzhou, China.
Yi MuThe First College of Clinical Medicine, Xuzhou Medical University, Xuzhou, China.
Xi WangThe First College of Clinical Medicine, Xuzhou Medical University, Xuzhou, China.
Naveena KonduruThe First College of Clinical Medicine, Xuzhou Medical University, Xuzhou, China.
Renlong JiThe First College of Clinical Medicine, Xuzhou Medical University, Xuzhou, China.
Wen LiuJiangsu Auditory Engineering Research Center, The Second College of Clinical Medicine, Xuzhou Medical University, Xuzhou, China.
Zhao FeiCentre for SLT and Hearing Sciences, Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, United Kingdom.
Wen JiangJiangsu Auditory Engineering Research Center, The Second College of Clinical Medicine, Xuzhou Medical University, Xuzhou, China.
Yuehua QiaoJiangsu Auditory Engineering Research Center, The Second College of Clinical Medicine, Xuzhou Medical University, Xuzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Inner ear disorders, such as EH, commonly lead to hearing loss and vestibular dysfunction. EH is particularly prevalent in various inner ear diseases, including Meniere's disease. We aimed to evaluate the effects of EH on WAI and OAEs. Objective: This study explores the potential of wideband acoustic immittance (WAI) and otoacoustic emissions (OAEs) for the early detection of changes in acoustic transmission associated with vasopressin-induced endolymphatic hydrops (EH) in a guinea pig model. Methods: We induced EH in guinea pigs via daily intraperitoneal injections of arginine vasopressin over 14 consecutive days. Auditory function was assessed using Auditory Brainstem Responses (ABR), while changes in sound energy transmission were measured using WAI and Distortion Products Otoacoustic Emissions (DPOAE). Results: Increased ABR thresholds in EH models were statistically significant ( Conclusion: WAI demonstrates greater sensitivity than DPOAE in the early detection of acoustic transmission alterations in EH models, suggesting its utility as a diagnostic tool in early-stage inner ear disorders.

Indexed as

ABRDPOAEendolymphatic hydropsguinea pigswideband acoustic immittance

Identifiers

PMID39916945
PMCPMC11800357

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.