Baricity of spinal bupivacaine and the incidence of hypotension in non-obstetric surgery: A systematic review.

Imré Van Herreweghe, Eline Ghysels, Jens Gielen, Robbert Buck, Elizabeth Flesher, Jirka Cops, Vera Saldien, Dieter Mesotten, Admir Hadzic

Abstract readReview

PubMed Full text at PMC Publisher

In one paragraph

Review in European journal of anaesthesiology and intensive care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Comparison of effectiveness and safety of spinal anaesthesia with 0.25% versus 0.5% hyperbaric bupivacaine for endoscopic urological procedures: A prospective randomised controlled trial.Indian journal of anaesthesia · 2026
Article
Intrathecal Nalbuphine Versus Other Opioids as Adjuvant to 0.5% Hyperbaric Bupivacaine in Caesarean Section: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Imré Van HerrewegheFrom the Department of Anaesthesiology, Ziekenhuis Oost-Limburg, Genk, Belgium (IVH, DM, AH), Department of Anaesthesiology, Universitair Ziekenhuis Antwerpen, Antwerp, Belgium (EG, VS), Department of Biomedical Sciences, Universiteit Hasselt, Hasselt, Belgium (JG), Department of Anaesthesiology, AZ Monica, Antwerp, Belgium (RB), Department of Anaesthesiology, UZ Leuven, Leuven, Belgium (EF) and New York School of Regional Anesthesia (NYSORA), New York, New York, USA (JC, AH).

Eline GhyselsFrom the Department of Anaesthesiology, Ziekenhuis Oost-Limburg, Genk, Belgium (IVH, DM, AH), Department of Anaesthesiology, Universitair Ziekenhuis Antwerpen, Antwerp, Belgium (EG, VS), Department of Biomedical Sciences, Universiteit Hasselt, Hasselt, Belgium (JG), Department of Anaesthesiology, AZ Monica, Antwerp, Belgium (RB), Department of Anaesthesiology, UZ Leuven, Leuven, Belgium (EF) and New York School of Regional Anesthesia (NYSORA), New York, New York, USA (JC, AH).

Jens GielenFrom the Department of Anaesthesiology, Ziekenhuis Oost-Limburg, Genk, Belgium (IVH, DM, AH), Department of Anaesthesiology, Universitair Ziekenhuis Antwerpen, Antwerp, Belgium (EG, VS), Department of Biomedical Sciences, Universiteit Hasselt, Hasselt, Belgium (JG), Department of Anaesthesiology, AZ Monica, Antwerp, Belgium (RB), Department of Anaesthesiology, UZ Leuven, Leuven, Belgium (EF) and New York School of Regional Anesthesia (NYSORA), New York, New York, USA (JC, AH).

Robbert BuckFrom the Department of Anaesthesiology, Ziekenhuis Oost-Limburg, Genk, Belgium (IVH, DM, AH), Department of Anaesthesiology, Universitair Ziekenhuis Antwerpen, Antwerp, Belgium (EG, VS), Department of Biomedical Sciences, Universiteit Hasselt, Hasselt, Belgium (JG), Department of Anaesthesiology, AZ Monica, Antwerp, Belgium (RB), Department of Anaesthesiology, UZ Leuven, Leuven, Belgium (EF) and New York School of Regional Anesthesia (NYSORA), New York, New York, USA (JC, AH).

Elizabeth FlesherFrom the Department of Anaesthesiology, Ziekenhuis Oost-Limburg, Genk, Belgium (IVH, DM, AH), Department of Anaesthesiology, Universitair Ziekenhuis Antwerpen, Antwerp, Belgium (EG, VS), Department of Biomedical Sciences, Universiteit Hasselt, Hasselt, Belgium (JG), Department of Anaesthesiology, AZ Monica, Antwerp, Belgium (RB), Department of Anaesthesiology, UZ Leuven, Leuven, Belgium (EF) and New York School of Regional Anesthesia (NYSORA), New York, New York, USA (JC, AH).

Jirka CopsFrom the Department of Anaesthesiology, Ziekenhuis Oost-Limburg, Genk, Belgium (IVH, DM, AH), Department of Anaesthesiology, Universitair Ziekenhuis Antwerpen, Antwerp, Belgium (EG, VS), Department of Biomedical Sciences, Universiteit Hasselt, Hasselt, Belgium (JG), Department of Anaesthesiology, AZ Monica, Antwerp, Belgium (RB), Department of Anaesthesiology, UZ Leuven, Leuven, Belgium (EF) and New York School of Regional Anesthesia (NYSORA), New York, New York, USA (JC, AH).

Vera SaldienFrom the Department of Anaesthesiology, Ziekenhuis Oost-Limburg, Genk, Belgium (IVH, DM, AH), Department of Anaesthesiology, Universitair Ziekenhuis Antwerpen, Antwerp, Belgium (EG, VS), Department of Biomedical Sciences, Universiteit Hasselt, Hasselt, Belgium (JG), Department of Anaesthesiology, AZ Monica, Antwerp, Belgium (RB), Department of Anaesthesiology, UZ Leuven, Leuven, Belgium (EF) and New York School of Regional Anesthesia (NYSORA), New York, New York, USA (JC, AH).

Dieter MesottenFrom the Department of Anaesthesiology, Ziekenhuis Oost-Limburg, Genk, Belgium (IVH, DM, AH), Department of Anaesthesiology, Universitair Ziekenhuis Antwerpen, Antwerp, Belgium (EG, VS), Department of Biomedical Sciences, Universiteit Hasselt, Hasselt, Belgium (JG), Department of Anaesthesiology, AZ Monica, Antwerp, Belgium (RB), Department of Anaesthesiology, UZ Leuven, Leuven, Belgium (EF) and New York School of Regional Anesthesia (NYSORA), New York, New York, USA (JC, AH).

Admir HadzicFrom the Department of Anaesthesiology, Ziekenhuis Oost-Limburg, Genk, Belgium (IVH, DM, AH), Department of Anaesthesiology, Universitair Ziekenhuis Antwerpen, Antwerp, Belgium (EG, VS), Department of Biomedical Sciences, Universiteit Hasselt, Hasselt, Belgium (JG), Department of Anaesthesiology, AZ Monica, Antwerp, Belgium (RB), Department of Anaesthesiology, UZ Leuven, Leuven, Belgium (EF) and New York School of Regional Anesthesia (NYSORA), New York, New York, USA (JC, AH).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bupivacaine is commonly used for spinal anaesthesia. The baricity of bupivacaine (isobaric

Identifiers

PMID39916940

DOI10.1097/EA9.0000000000000064

PMCPMC11798388

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.