Evidence map›Paper›PMID 39916820›Full record

ArticleEuropean journal of anaesthesiology and intensive care2024

The effects of anaesthesia and analgesia on short- and long-term outcomes following colorectal cancer surgery: Protocol for an international, pragmatic, cohort study (ENCORE∗).

Max Bell, Donal J Buggy, Daniel Brattström, Christian Buchli, Sophie Debouche, Fredrik Granath, Bernard Riedel, Anil Gupta

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of anaesthesiology and intensive care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04493905 (The Effects of Anesthetic Techniques on Time to Start of Adjuvant Chemotherapy, and Early- and Late-outcomes Following Surgery for Colorectal Cancer A Prospective, Multicenter, International, Observational, Pragmatic Study), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04493905 completednot on this map

The Effects of Anesthetic Techniques on Time to Start of Adjuvant Chemotherapy, and Early- and Late-outcomes Following Surgery for Colorectal Cancer A Prospective, Multicenter, International, Observational, Pragmatic Study

TypeobservationalSponsorEuropean Society of AnaesthesiologyRan2021 to 2024Enrolled5,500ConditionsColorectal Neoplasms, Anesthesia, Drug Therapy, Surgery
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Max BellFrom the Department of Anaesthesia and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden (MB, AG), Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (MB, AG), Mater Misericordiae University Hospital, School of Medicine, University College Dublin, Ireland (DJB), EuroPeriscope, The ESA-IC OncoAnaesthesiology Research Group (DJB, AG), Department of Oncology, Karolinska University Hospital, Stockholm, SWEDEN (DB), Department of Pelvic Cancer, GI Oncology and Colorectal Surgery Unit, Karolinska University Hospital, and Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (CB), Clinical Trial Coordinator, European Society of Anaesthesiology and Intensive Care, Brussels, Belgium (SD), Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (FG), Department of Anaesthesia, Perioperative Medicine, and Pain Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia (BR), Department of Critical Care, University of Melbourne, Melbourne, Australia (BR), The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia (BR).
Donal J BuggyFrom the Department of Anaesthesia and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden (MB, AG), Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (MB, AG), Mater Misericordiae University Hospital, School of Medicine, University College Dublin, Ireland (DJB), EuroPeriscope, The ESA-IC OncoAnaesthesiology Research Group (DJB, AG), Department of Oncology, Karolinska University Hospital, Stockholm, SWEDEN (DB), Department of Pelvic Cancer, GI Oncology and Colorectal Surgery Unit, Karolinska University Hospital, and Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (CB), Clinical Trial Coordinator, European Society of Anaesthesiology and Intensive Care, Brussels, Belgium (SD), Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (FG), Department of Anaesthesia, Perioperative Medicine, and Pain Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia (BR), Department of Critical Care, University of Melbourne, Melbourne, Australia (BR), The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia (BR).
Daniel BrattströmFrom the Department of Anaesthesia and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden (MB, AG), Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (MB, AG), Mater Misericordiae University Hospital, School of Medicine, University College Dublin, Ireland (DJB), EuroPeriscope, The ESA-IC OncoAnaesthesiology Research Group (DJB, AG), Department of Oncology, Karolinska University Hospital, Stockholm, SWEDEN (DB), Department of Pelvic Cancer, GI Oncology and Colorectal Surgery Unit, Karolinska University Hospital, and Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (CB), Clinical Trial Coordinator, European Society of Anaesthesiology and Intensive Care, Brussels, Belgium (SD), Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (FG), Department of Anaesthesia, Perioperative Medicine, and Pain Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia (BR), Department of Critical Care, University of Melbourne, Melbourne, Australia (BR), The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia (BR).
Christian BuchliFrom the Department of Anaesthesia and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden (MB, AG), Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (MB, AG), Mater Misericordiae University Hospital, School of Medicine, University College Dublin, Ireland (DJB), EuroPeriscope, The ESA-IC OncoAnaesthesiology Research Group (DJB, AG), Department of Oncology, Karolinska University Hospital, Stockholm, SWEDEN (DB), Department of Pelvic Cancer, GI Oncology and Colorectal Surgery Unit, Karolinska University Hospital, and Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (CB), Clinical Trial Coordinator, European Society of Anaesthesiology and Intensive Care, Brussels, Belgium (SD), Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (FG), Department of Anaesthesia, Perioperative Medicine, and Pain Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia (BR), Department of Critical Care, University of Melbourne, Melbourne, Australia (BR), The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia (BR).
Sophie DeboucheFrom the Department of Anaesthesia and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden (MB, AG), Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (MB, AG), Mater Misericordiae University Hospital, School of Medicine, University College Dublin, Ireland (DJB), EuroPeriscope, The ESA-IC OncoAnaesthesiology Research Group (DJB, AG), Department of Oncology, Karolinska University Hospital, Stockholm, SWEDEN (DB), Department of Pelvic Cancer, GI Oncology and Colorectal Surgery Unit, Karolinska University Hospital, and Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (CB), Clinical Trial Coordinator, European Society of Anaesthesiology and Intensive Care, Brussels, Belgium (SD), Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (FG), Department of Anaesthesia, Perioperative Medicine, and Pain Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia (BR), Department of Critical Care, University of Melbourne, Melbourne, Australia (BR), The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia (BR).
Fredrik GranathFrom the Department of Anaesthesia and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden (MB, AG), Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (MB, AG), Mater Misericordiae University Hospital, School of Medicine, University College Dublin, Ireland (DJB), EuroPeriscope, The ESA-IC OncoAnaesthesiology Research Group (DJB, AG), Department of Oncology, Karolinska University Hospital, Stockholm, SWEDEN (DB), Department of Pelvic Cancer, GI Oncology and Colorectal Surgery Unit, Karolinska University Hospital, and Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (CB), Clinical Trial Coordinator, European Society of Anaesthesiology and Intensive Care, Brussels, Belgium (SD), Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (FG), Department of Anaesthesia, Perioperative Medicine, and Pain Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia (BR), Department of Critical Care, University of Melbourne, Melbourne, Australia (BR), The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia (BR).
Bernard RiedelFrom the Department of Anaesthesia and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden (MB, AG), Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (MB, AG), Mater Misericordiae University Hospital, School of Medicine, University College Dublin, Ireland (DJB), EuroPeriscope, The ESA-IC OncoAnaesthesiology Research Group (DJB, AG), Department of Oncology, Karolinska University Hospital, Stockholm, SWEDEN (DB), Department of Pelvic Cancer, GI Oncology and Colorectal Surgery Unit, Karolinska University Hospital, and Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (CB), Clinical Trial Coordinator, European Society of Anaesthesiology and Intensive Care, Brussels, Belgium (SD), Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (FG), Department of Anaesthesia, Perioperative Medicine, and Pain Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia (BR), Department of Critical Care, University of Melbourne, Melbourne, Australia (BR), The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia (BR).
Anil GuptaFrom the Department of Anaesthesia and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden (MB, AG), Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (MB, AG), Mater Misericordiae University Hospital, School of Medicine, University College Dublin, Ireland (DJB), EuroPeriscope, The ESA-IC OncoAnaesthesiology Research Group (DJB, AG), Department of Oncology, Karolinska University Hospital, Stockholm, SWEDEN (DB), Department of Pelvic Cancer, GI Oncology and Colorectal Surgery Unit, Karolinska University Hospital, and Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (CB), Clinical Trial Coordinator, European Society of Anaesthesiology and Intensive Care, Brussels, Belgium (SD), Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden (FG), Department of Anaesthesia, Perioperative Medicine, and Pain Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia (BR), Department of Critical Care, University of Melbourne, Melbourne, Australia (BR), The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia (BR).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is the second most frequent cause of global cancer mortality. Most patients with CRC require surgical tumour resection, with certain stages of CRC (Stage II/III) also requiring postoperative chemotherapy. The timing of postoperative chemotherapy is largely determined by postoperative recovery. Delayed return to intended oncologic therapy (RIOT) by >8 weeks results in worse oncologic outcomes. RIOT is thus an important surrogate marker of outcome for patients with stage II/III CRC. We will test the hypothesis that anaesthetic technique during CRC resection surgery may affect RIOT.

objectiveTo test the association between anaesthetic and analgesic technique during CRC surgery and RIOT. To document Short-term Secondary outcomes including individual postoperative complications and a composite of all postoperative complications, the Comprehensive Complications Index (CCI) and to measure the time to recurrence (TTR) of cancer at 3 years.

designThis is a prospective, international, multicentre, observational cohort study.

settingGlobal healthcare setting, with >140 centres in >30 nations. PATIENTS: Inclusion criteria: All patients age >18 years, ASA I-III, with CRC stage I-III scheduled for elective CRC surgery (open or minimally invasive).Exclusion criteria: Uncontrolled renal or liver disease, restrictive (limiting mobility) heart failure or ischemic heart disease (ASA IV-V). Speech, language, or cognitive difficulties precluding signing informed consent to participate and Stage IV CRC. PRIMARY OUTCOME MEASURES: Short -term: The duration from day of surgery to RIOT among patients expected to receive postoperative chemotherapy. Long-term: incidence of recurrence and time to recurrence (TTR) at 3 years after primary curative surgery. SECONDARY OUTCOMES: Postoperative complications within 30 days of surgery, length of hospital stay, Days at Home at 30 and 90 days (DAH-30, DAH-90) after surgery, and adverse events related to oncological treatment. We will also assess the burden of preoperative modifiable comorbid disease in patients. Exploratory endpoints will assess practice variation (including incidence of RIOT by demographic e.g. gender of patient, type of institution, country).

resultsN/A.

conclusionsN/A.

trial registrationThe Effects of aNesthesia in COloREctal cancer outcome study: ENCORE, ClinicalTrials.gov Identifier: NCT04493905.

Identifiers

PMID39916820
PMCPMC11798386

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