Evidence map›Paper›PMID 39916748›Full record

ArticleGut microbes reports2024

Comparison Between Two Divergent Diets, Mediterranean and Western, on Gut Microbiota and Cognitive Function in Young Sprague Dawley Rats.

Rebecca J Solch-Ottaiano, Elizabeth B Engler-Chiurazzi, Colin Harper, Savannah Wasson, Sharon Ogbonna, Blake Ouvrier, Hanyun Wang, Madison Prats, Katherine McDonald, Ifechukwude J Biose and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rebecca J Solch-OttaianoClinical Neuroscience Research Center, Department of Neurology, Tulane University School of Medicine, New Orleans, LA, USA.
Elizabeth B Engler-ChiurazziTulane Brain Institute, Tulane University, New Orleans, LA, USA.
Colin HarperClinical Neuroscience Research Center, Department of Neurology, Tulane University School of Medicine, New Orleans, LA, USA.
Savannah WassonClinical Neuroscience Research Center, Department of Neurology, Tulane University School of Medicine, New Orleans, LA, USA.
Sharon OgbonnaClinical Neuroscience Research Center, Department of Neurology, Tulane University School of Medicine, New Orleans, LA, USA.
Blake OuvrierTulane Brain Institute, Tulane University, New Orleans, LA, USA.
Hanyun WangClinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA, USA.
Madison PratsClinical Neuroscience Research Center, Department of Neurology, Tulane University School of Medicine, New Orleans, LA, USA.
Katherine McDonaldClinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA, USA.
Ifechukwude J BioseTulane Brain Institute, Tulane University, New Orleans, LA, USA.
Lori A RoweVirus Characterization, Isolation, Production and Sequencing Core, Department of Microbiology, Tulane National Primate Center, Covington, LA, USA.
MaryJane JonesDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
Chad SteeleDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
Gregory BixTulane Brain Institute, Tulane University, New Orleans, LA, USA.
Demetrius M MaraganoreClinical Neuroscience Research Center, Department of Neurology, Tulane University School of Medicine, New Orleans, LA, USA.

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
The role of the CMV-associated reactive oxygen species in age-relatedP20GM103629 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI TIAN, AIGUO · 2012 to 2021
$22.4M
PROJECT PATHWAYS: STUDENT TRAINING CORETL4GM118968 · NIGMS · XAVIER UNIVERSITY OF LOUISIANA · PI FOROOZESH, MARYAM, GIGUETTE, MARGUERITE · 2015 to 2023
$9.2M
NIGMS NIH HHS P20 GM103629NIGMS NIH HHS TL4 GM118968NIH HHS P51 OD011104
6 · The paper itself

Abstract

Clinical studies strongly suggest the importance of diet quality on cognition in youth populations (15-24 years). The Mediterranean diet (MeDi) has been shown to improve cognition in contrast to the commonly consumed Western diet (WD). The gut microbiota may serve as a mechanism for diet-induced changes in cognition. Ten-week-old male Sprague Dawley rats were assigned a MeDi or WD (n=10/group) for 14 weeks. Prior to neurobehavior assessments, microbiota community composition was assessed. At the genus level, the relative abundance of four bacteria increased with the MeDi and five decreased compared to the WD. Rats in the MeDi group demonstrated cognitive flexibility and improvement in reference and working memory relative to the WD group. At the end of the study, serum cytokines were increased, and low-density lipoproteins were decreased in the MeDi group. Markers for neuroinflammation, blood-brain barrier, glial cells, and synaptic plasticity in brain regions did not differ between groups. Overall, the MeDi modulated gut microbiota, cognitive function, and serum lipid and cytokines but not gene expression in the brain compared to the WD. Further studies are needed to determine causality between diet-modulated gut microbiota, cognitive function, and immune function.

Indexed as

Cognitive FunctionGut microbiotaMediterranean dietMemoryWestern diet

Identifiers

PMID39916748
PMCPMC11800364

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.