Evidence map›Paper›PMID 39916726›Full record

ArticleEuropean journal of anaesthesiology and intensive care2023

Critical and non-critical coronavirus disease 2019 patients: which is the most predictive biomarker for disease severity and outcome?: A multicentre prospective cohort study comparing mid-regional pro-adrenomedullin, inflammatory and immunological patterns.

Giorgia Montrucchio, Eleonora Balzani, Gabriele Sales, Cesare Bolla, Cristina Sarda, Andrea Della Selva, Massimo Perotto, Fulvio Pomero, Enrico Ravera, Francesca Rumbolo and 4 more

Registry-linked trialAbstract read
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In one paragraph

Article in European journal of anaesthesiology and intensive care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04873388 (Biomarkers and Early Predictors of Prognostic Course, Response to Possible to Possible Treatments and Risk of Over-infection in Patients With COVID-19 Hospitalized in the Critical or Semi-intensive Area.), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04873388 unknown statusnot on this map

Biomarkers and Early Predictors of Prognostic Course, Response to Possible to Possible Treatments and Risk of Over-infection in Patients With COVID-19 Hospitalized in the Critical or Semi-intensive Area.

TypeobservationalSponsorUniversity of Turin, ItalyRan2020 to 2024Enrolled150ConditionsCovid19, C-reactive Protein, Procalcitonin, D-dimer
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Giorgia MontrucchioFrom the Department of Surgical Sciences, University of Turin (GM, EB, GS, VF, lB), Department of Anaesthesia, Critical Care and Emergency - Città Della Salute e Della Scienza Hospital, Turin (GM, GS, VF, LB), Unit of Infectious Diseases, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (CB, CS), Department of Emergency, Anesthesia and Critical Care Medicine (ADS, ER), Department of Emergency Medicine (MP), Department of Internal Medicine, Michele e Pietro Ferrero Hospital, Verduno (FP), Clinical Biochemistry Laboratory, Città Della Salute e Della Scienza Hospital, Torino (FR, GM), Clinical Biochemistry Laboratory, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (TC) and Department of Medical Sciences, University of Turin, Torino, Italy (GM).
Eleonora BalzaniFrom the Department of Surgical Sciences, University of Turin (GM, EB, GS, VF, lB), Department of Anaesthesia, Critical Care and Emergency - Città Della Salute e Della Scienza Hospital, Turin (GM, GS, VF, LB), Unit of Infectious Diseases, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (CB, CS), Department of Emergency, Anesthesia and Critical Care Medicine (ADS, ER), Department of Emergency Medicine (MP), Department of Internal Medicine, Michele e Pietro Ferrero Hospital, Verduno (FP), Clinical Biochemistry Laboratory, Città Della Salute e Della Scienza Hospital, Torino (FR, GM), Clinical Biochemistry Laboratory, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (TC) and Department of Medical Sciences, University of Turin, Torino, Italy (GM).
Gabriele SalesFrom the Department of Surgical Sciences, University of Turin (GM, EB, GS, VF, lB), Department of Anaesthesia, Critical Care and Emergency - Città Della Salute e Della Scienza Hospital, Turin (GM, GS, VF, LB), Unit of Infectious Diseases, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (CB, CS), Department of Emergency, Anesthesia and Critical Care Medicine (ADS, ER), Department of Emergency Medicine (MP), Department of Internal Medicine, Michele e Pietro Ferrero Hospital, Verduno (FP), Clinical Biochemistry Laboratory, Città Della Salute e Della Scienza Hospital, Torino (FR, GM), Clinical Biochemistry Laboratory, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (TC) and Department of Medical Sciences, University of Turin, Torino, Italy (GM).
Cesare BollaFrom the Department of Surgical Sciences, University of Turin (GM, EB, GS, VF, lB), Department of Anaesthesia, Critical Care and Emergency - Città Della Salute e Della Scienza Hospital, Turin (GM, GS, VF, LB), Unit of Infectious Diseases, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (CB, CS), Department of Emergency, Anesthesia and Critical Care Medicine (ADS, ER), Department of Emergency Medicine (MP), Department of Internal Medicine, Michele e Pietro Ferrero Hospital, Verduno (FP), Clinical Biochemistry Laboratory, Città Della Salute e Della Scienza Hospital, Torino (FR, GM), Clinical Biochemistry Laboratory, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (TC) and Department of Medical Sciences, University of Turin, Torino, Italy (GM).
Cristina SardaFrom the Department of Surgical Sciences, University of Turin (GM, EB, GS, VF, lB), Department of Anaesthesia, Critical Care and Emergency - Città Della Salute e Della Scienza Hospital, Turin (GM, GS, VF, LB), Unit of Infectious Diseases, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (CB, CS), Department of Emergency, Anesthesia and Critical Care Medicine (ADS, ER), Department of Emergency Medicine (MP), Department of Internal Medicine, Michele e Pietro Ferrero Hospital, Verduno (FP), Clinical Biochemistry Laboratory, Città Della Salute e Della Scienza Hospital, Torino (FR, GM), Clinical Biochemistry Laboratory, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (TC) and Department of Medical Sciences, University of Turin, Torino, Italy (GM).
Andrea Della SelvaFrom the Department of Surgical Sciences, University of Turin (GM, EB, GS, VF, lB), Department of Anaesthesia, Critical Care and Emergency - Città Della Salute e Della Scienza Hospital, Turin (GM, GS, VF, LB), Unit of Infectious Diseases, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (CB, CS), Department of Emergency, Anesthesia and Critical Care Medicine (ADS, ER), Department of Emergency Medicine (MP), Department of Internal Medicine, Michele e Pietro Ferrero Hospital, Verduno (FP), Clinical Biochemistry Laboratory, Città Della Salute e Della Scienza Hospital, Torino (FR, GM), Clinical Biochemistry Laboratory, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (TC) and Department of Medical Sciences, University of Turin, Torino, Italy (GM).
Massimo PerottoFrom the Department of Surgical Sciences, University of Turin (GM, EB, GS, VF, lB), Department of Anaesthesia, Critical Care and Emergency - Città Della Salute e Della Scienza Hospital, Turin (GM, GS, VF, LB), Unit of Infectious Diseases, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (CB, CS), Department of Emergency, Anesthesia and Critical Care Medicine (ADS, ER), Department of Emergency Medicine (MP), Department of Internal Medicine, Michele e Pietro Ferrero Hospital, Verduno (FP), Clinical Biochemistry Laboratory, Città Della Salute e Della Scienza Hospital, Torino (FR, GM), Clinical Biochemistry Laboratory, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (TC) and Department of Medical Sciences, University of Turin, Torino, Italy (GM).
Fulvio PomeroFrom the Department of Surgical Sciences, University of Turin (GM, EB, GS, VF, lB), Department of Anaesthesia, Critical Care and Emergency - Città Della Salute e Della Scienza Hospital, Turin (GM, GS, VF, LB), Unit of Infectious Diseases, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (CB, CS), Department of Emergency, Anesthesia and Critical Care Medicine (ADS, ER), Department of Emergency Medicine (MP), Department of Internal Medicine, Michele e Pietro Ferrero Hospital, Verduno (FP), Clinical Biochemistry Laboratory, Città Della Salute e Della Scienza Hospital, Torino (FR, GM), Clinical Biochemistry Laboratory, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (TC) and Department of Medical Sciences, University of Turin, Torino, Italy (GM).
Enrico RaveraFrom the Department of Surgical Sciences, University of Turin (GM, EB, GS, VF, lB), Department of Anaesthesia, Critical Care and Emergency - Città Della Salute e Della Scienza Hospital, Turin (GM, GS, VF, LB), Unit of Infectious Diseases, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (CB, CS), Department of Emergency, Anesthesia and Critical Care Medicine (ADS, ER), Department of Emergency Medicine (MP), Department of Internal Medicine, Michele e Pietro Ferrero Hospital, Verduno (FP), Clinical Biochemistry Laboratory, Città Della Salute e Della Scienza Hospital, Torino (FR, GM), Clinical Biochemistry Laboratory, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (TC) and Department of Medical Sciences, University of Turin, Torino, Italy (GM).
Francesca RumboloFrom the Department of Surgical Sciences, University of Turin (GM, EB, GS, VF, lB), Department of Anaesthesia, Critical Care and Emergency - Città Della Salute e Della Scienza Hospital, Turin (GM, GS, VF, LB), Unit of Infectious Diseases, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (CB, CS), Department of Emergency, Anesthesia and Critical Care Medicine (ADS, ER), Department of Emergency Medicine (MP), Department of Internal Medicine, Michele e Pietro Ferrero Hospital, Verduno (FP), Clinical Biochemistry Laboratory, Città Della Salute e Della Scienza Hospital, Torino (FR, GM), Clinical Biochemistry Laboratory, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (TC) and Department of Medical Sciences, University of Turin, Torino, Italy (GM).
Tiziana CallegariFrom the Department of Surgical Sciences, University of Turin (GM, EB, GS, VF, lB), Department of Anaesthesia, Critical Care and Emergency - Città Della Salute e Della Scienza Hospital, Turin (GM, GS, VF, LB), Unit of Infectious Diseases, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (CB, CS), Department of Emergency, Anesthesia and Critical Care Medicine (ADS, ER), Department of Emergency Medicine (MP), Department of Internal Medicine, Michele e Pietro Ferrero Hospital, Verduno (FP), Clinical Biochemistry Laboratory, Città Della Salute e Della Scienza Hospital, Torino (FR, GM), Clinical Biochemistry Laboratory, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (TC) and Department of Medical Sciences, University of Turin, Torino, Italy (GM).
Vito FanelliFrom the Department of Surgical Sciences, University of Turin (GM, EB, GS, VF, lB), Department of Anaesthesia, Critical Care and Emergency - Città Della Salute e Della Scienza Hospital, Turin (GM, GS, VF, LB), Unit of Infectious Diseases, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (CB, CS), Department of Emergency, Anesthesia and Critical Care Medicine (ADS, ER), Department of Emergency Medicine (MP), Department of Internal Medicine, Michele e Pietro Ferrero Hospital, Verduno (FP), Clinical Biochemistry Laboratory, Città Della Salute e Della Scienza Hospital, Torino (FR, GM), Clinical Biochemistry Laboratory, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (TC) and Department of Medical Sciences, University of Turin, Torino, Italy (GM).
Giulio MengozziFrom the Department of Surgical Sciences, University of Turin (GM, EB, GS, VF, lB), Department of Anaesthesia, Critical Care and Emergency - Città Della Salute e Della Scienza Hospital, Turin (GM, GS, VF, LB), Unit of Infectious Diseases, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (CB, CS), Department of Emergency, Anesthesia and Critical Care Medicine (ADS, ER), Department of Emergency Medicine (MP), Department of Internal Medicine, Michele e Pietro Ferrero Hospital, Verduno (FP), Clinical Biochemistry Laboratory, Città Della Salute e Della Scienza Hospital, Torino (FR, GM), Clinical Biochemistry Laboratory, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (TC) and Department of Medical Sciences, University of Turin, Torino, Italy (GM).
Luca BrazziFrom the Department of Surgical Sciences, University of Turin (GM, EB, GS, VF, lB), Department of Anaesthesia, Critical Care and Emergency - Città Della Salute e Della Scienza Hospital, Turin (GM, GS, VF, LB), Unit of Infectious Diseases, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (CB, CS), Department of Emergency, Anesthesia and Critical Care Medicine (ADS, ER), Department of Emergency Medicine (MP), Department of Internal Medicine, Michele e Pietro Ferrero Hospital, Verduno (FP), Clinical Biochemistry Laboratory, Città Della Salute e Della Scienza Hospital, Torino (FR, GM), Clinical Biochemistry Laboratory, ASO SS. Antonio e Biagio e Cesare Arrigo, Alessandria (TC) and Department of Medical Sciences, University of Turin, Torino, Italy (GM).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere acute respiratory syndrome-coronavirus-2 in coronavirus disease 2019 (COVID-19) patients leads to a wide range of clinical manifestations. The evaluation of mid-regional pro-adrenomedullin (MR-proADM) as a prognostic biomarker in noncritical wards (NON-ICU) and intensive care units (ICU), may have a potential in predicting disease severity and outcomes.

objectiveTo assess the difference in the prognostic power of MR-proADM in NON-ICU wards and in ICUs in a prospective multicentre cohort study.

designFrom January to July 2021, all adult COVID-19 patients requiring admission for more than 48 h.

settingOne primary centre and two secondary centre hospitals. PATIENTS: One hundred and twenty-three ICU and 77 NON-ICU patients.

interventionMR-proADM, lymphocyte subpopulations and immunoglobulins were measured within 48 h and on days 3 and 7. A Log-rank test was used to compare survival curves, using a MR-proADM cut-off value of 1.5 nmol l

main outcome measuresThe first 48 h MR-proADM values were significantly higher in the ICU group (median value 1.10 [IQR, 0.80 to 1.73] pg ml

conclusionMR-proADM admission values and trends over time appear to be a suitable marker of illness severity and a patient's risk of mortality in both ICU and NON-ICU settings. Lymphocyte subpopulation dysfunction seems to play a role in defining the severity of COVID-19 but is limited to ICU setting.

trial registrationon clinicaltrials.gov, NCT04873388 registered on March 2020.

Identifiers

PMID39916726
PMCPMC11798374

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