ArticleThe Journal of dermatology2025
Validation of Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score and establishment of novel score in Japanese patients with necrotizing fasciitis (J-LRINEC score).
Article in The Journal of dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Progressive isolated lower-lip oedema after mRNA COVID-19 booster complicated by methicillin-resistantSkin health and disease · 2026Article
- CT of Soft Tissue Infections: Current and Future Perspectives from Diagnosis to Treatment.Journal of clinical medicine · 2026Review
- Risk factors and predictors of in-hospital mortality in necrotizing fasciitis: a five-year retrospective cohort study from a tertiary care center in Colombia.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Explainable machine learning differentiates necrotizing fasciitis and osteomyelitis via routine blood biomarkers.NPJ digital medicine · 2026Article
- Necrotizing Fasciitis Camouflaging As Cellulitis: A Case Report Highlighting Diagnostic Pitfalls.Cureus · 2026Article
- Association between the direct bilirubin to lymphocyte ratio and mortality in patients with necrotizing fasciitis: a retrospective cohort study.Frontiers in medicine · 2026Article
- Diagnostic strategies in necrotizing soft tissue infections: from clinical scores to multi-omics and machine learning.Burns & trauma · 2026Review
- Multiple skip incision skin-sparing debridement for perianal necrotizing fasciitis: a retrospective study.World journal of emergency surgery : WJES · 2025Article
- Predictive Models for Necrotizing Soft Tissue Infections: Are the Available Scores Trustable?Journal of clinical medicine · 2025Review
- Validation of Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score and establishment of novel score in Japanese patients with necrotizing fasciitis (J-LRINEC score).The Journal of dermatology · 2025Article
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13 authors.
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Abstract
The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score is widely used to distinguish between necrotizing fasciitis and cellulitis. However, LRINEC scores are not as sensitive or specific as initially reported, possibly due to differences in patient backgrounds in different countries. Here, we examined the validity of LRINEC scores in Japanese patients. We also investigated the possibility of developing a new scoring system. Patients with necrotizing fasciitis (n = 56) and cellulitis (n = 209) were retrospectively evaluated. The data were split into training (n = 199) and validation (n = 66) datasets. A logistic regression analysis was used to calculate the C-statistics of the LRINEC scores. A new equation was formulated using logistic regression analysis with an appropriate variable selection (Laboratory Risk Indicator for Necrotizing Fasciitis for Japanese Patients [J-LRINEC] score). The J-LRINEC score had a C-statistic of 0.9683, sensitivity of 91.4%, and specificity of 84.8%. The LRINEC score had a C-statistic of 0.914 and specificity of 96%; however, its usefulness was limited by its sensitivity of 68.9%. Our results suggest that the LRINEC score is valid for Japanese patients; however, the J-LRINEC score showed higher sensitivity and specificity, suggesting that it may be a useful tool for differentiating cellulitis from necrotizing fasciitis among Japanese patients.
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