Evidence map›Paper›PMID 39916608›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2025

Tick-borne encephalitis: from tick surveillance to the first confirmed human cases, the United Kingdom, 2015 to 2023.

Helen Callaby, Kate R Beard, Dominic Wakerley, Mary Alexandra Lake, Jane Osborne, Kevin Brown, Nadina Wand, Jenny Warner, Maya Holding, Nicholas Ws Davies and 9 more

Abstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. New Aspects on Tick-borne Encephalitis in Children.The Pediatric infectious disease journal · 2026
    Article
  5. Article
  6. Tick-Borne Encephalitis in the 21Le infezioni in medicina · 2026
    Review
  7. Article
  8. Design and implementation of blood donor sample bioarchives to enhance preparedness for emerging and pandemic pathogens in England.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  9. Review
  10. Identifying hotspots and risk factors for tick-borne encephalitis virus emergence at its range margins to guide interventions, Great Britain.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Helen CallabyUnited Kingdom Health Security Agency (UKHSA) Rare and Imported Pathogens Laboratory, Porton Down, Salisbury, United Kingdom.
Kate R BeardUnited Kingdom Health Security Agency (UKHSA) Rare and Imported Pathogens Laboratory, Porton Down, Salisbury, United Kingdom.
Dominic WakerleyUnited Kingdom Health Security Agency (UKHSA) Rare and Imported Pathogens Laboratory, Porton Down, Salisbury, United Kingdom.
Mary Alexandra LakeUnited Kingdom Health Security Agency (UKHSA) Rare and Imported Pathogens Laboratory, Porton Down, Salisbury, United Kingdom.
Jane OsborneUnited Kingdom Health Security Agency (UKHSA) Rare and Imported Pathogens Laboratory, Porton Down, Salisbury, United Kingdom.
Kevin BrownUnited Kingdom Health Security Agency (UKHSA) Virus Reference Department, Colindale, United Kingdom.
Nadina WandNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Jenny WarnerUnited Kingdom Health Security Agency (UKHSA) Diagnostics and Pathogen Characterisation Division, Porton Down, Salisbury, United Kingdom.
Maya HoldingUnited Kingdom Health Security Agency (UKHSA) Diagnostics and Pathogen Characterisation Division, Porton Down, Salisbury, United Kingdom.
Nicholas Ws DaviesImperial College Healthcare National Health Service (NHS) Trust, London, United Kingdom.
Malcolm ProudfootYork and Scarborough Teaching Hospitals, York, United Kingdom.
Amanda SemperUnited Kingdom Health Security Agency (UKHSA) Rare and Imported Pathogens Laboratory, Porton Down, Salisbury, United Kingdom.
Tim BrooksUnited Kingdom Health Security Agency (UKHSA) Rare and Imported Pathogens Laboratory, Porton Down, Salisbury, United Kingdom.
Christina PetridouUnited Kingdom Health Security Agency (UKHSA) Rare and Imported Pathogens Laboratory, Porton Down, Salisbury, United Kingdom.
Catherine F HoulihanUnited Kingdom Health Security Agency (UKHSA) Rare and Imported Pathogens Laboratory, Porton Down, Salisbury, United Kingdom.
Tommy RamplingUnited Kingdom Health Security Agency (UKHSA) Rare and Imported Pathogens Laboratory, Porton Down, Salisbury, United Kingdom.
Clare E WarrellUnited Kingdom Health Security Agency (UKHSA) Rare and Imported Pathogens Laboratory, Porton Down, Salisbury, United Kingdom.
N Claire GordonUnited Kingdom Health Security Agency (UKHSA) Rare and Imported Pathogens Laboratory, Porton Down, Salisbury, United Kingdom.
TBE working groupThe members of the TBE working group are listed under Collaborators.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundTick-borne encephalitis virus (TBEV) is a flavivirus spread by ticks and can cause tick-borne encephalitis (TBE) in humans. Previously, TBE has been reported in returning travellers in the United Kingdom (UK), but in 2019 and 2020, two probable cases of TBE acquired in the UK were identified.AimThe aim of this study was to investigate TBE cases in the UK between 2015 and 2023, describing the incidence, place and mode of acquisition and diagnostic process.MethodsA retrospective review of possible, probable and confirmed cases of TBE diagnosed by the Rare and Imported Pathogens Laboratory (RIPL) between January 2015 and December 2023 was performed. For cases identified in 2022 and 2023, clinical data were collected for enhanced surveillance using structured case record forms. Laboratory diagnosis is reviewed and described.ResultsWe identified 21 cases: three possible, seven probable and 11 confirmed cases. Of these, 12 were between January 2022 and December 2023: three possible, three probable and six confirmed cases. Two confirmed TBE cases had definite or highly probable acquisition in the UK, in June and August 2022, respectively. One of the possible cases had definite UK acquisition. Cases typically have a biphasic presentation, with encephalitis in the second phase.ConclusionClinicians should be aware of the possibility of TBE when the cause for encephalitis is not identified, even in the absence of travel to previously identified endemic regions.

Indexed as

Encephalitis, Tick-BorneEncephalitis Viruses, Tick-BorneTicksAdolescentAdultAgedAnimalsFemaleHumansIncidenceMaleMiddle AgedPopulation SurveillanceRetrospective StudiesTravelUnited KingdomTick-borne encephalitisVector-borne disease

Identifiers

PMID39916608
PMCPMC11803743

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.