ArticleMolecular therapy : the journal of the American Society of Gene Therapy2025
Converting TCR-based chimeric antigen receptor STAR into dual-specific targeting receptor for cancer immunotherapy.
Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Chimeric antigen receptor (CAR)-T cell therapy for solid tumors in pediatric patients: current breakthroughs, dilemmas, and strategies.Experimental hematology & oncology · 2026Review
- Dual epitope anti-LILRB4 synthetic T-cell receptor and antigen receptor (STAR)-T-cell therapy for relapsed/refractory acute myeloid leukemia.Signal transduction and targeted therapy · 2026Article
- CAR-T cell signaling dynamics, rational design principles and artificial intelligence for next-generation chimeric antigen receptors.Frontiers in immunology · 2026Review
- CAR-T cell therapy for cancer: current challenges and future directions.Signal transduction and targeted therapy · 2025Review
- Transitioning from native to synthetic receptors: broadening T-cell engineering and beyond.Cellular & molecular immunology · 2025Review
- D-STAR: The Gemini Guardians redefining dual-targeting of immune cell therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chimeric antigen receptor (CAR) T cell therapy has achieved great success in treating hematopoietic malignancies; however, post-therapy relapse remains a challenge. Traditionally, multi-specific CAR engineering requires precise arrangement of single-chain variable fragments (scFvs), which can lead to aggregation issues when assembled linearly. In this study, we developed a novel chimeric receptor, the dual-targeting synthetic TCR and antigen receptor (D-STAR). D-STAR exhibited structural advantages, activating T cells and inducing effector functions in response to single antigen stimulation while mediating robust killing against various malignant B cells. In mouse models, D-STAR demonstrated superior antitumor efficacy compared to single- and dual-targeting CAR-T cells. To enhance its effectiveness, we integrated the OX40 costimulatory cytoplasmic domain with flexible linkers, boosting T cell proliferation and fitness under higher tumor burdens in vivo. This study illustrates the superior structural capacity and antitumor potency of D-STAR T cells.
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Registered trials
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