Evidence map›Paper›PMID 39915959›Full record

ArticleJournal of proteome research2025

TIMS

Arthur Declercq, Robbe Devreese, Jonas Scheid, Caroline Jachmann, Tim Van Den Bossche, Annica Preikschat, David Gomez-Zepeda, Jeewan Babu Rijal, Aurélie Hirschler, Jonathan R Krieger and 11 more

Abstract read
In one paragraph

Article in Journal of proteome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Arthur DeclercqVIB-UGent Center for Medical Biotechnology, VIB, Ghent 9052, Belgium.ORCID 0000-0002-9376-1399
Robbe DevreeseVIB-UGent Center for Medical Biotechnology, VIB, Ghent 9052, Belgium.ORCID 0000-0002-3432-1502
Jonas ScheidDepartment of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen 72076, Germany.ORCID 0000-0002-5923-1343
Caroline JachmannVIB-UGent Center for Medical Biotechnology, VIB, Ghent 9052, Belgium.ORCID 0009-0000-4679-7295
Tim Van Den BosscheVIB-UGent Center for Medical Biotechnology, VIB, Ghent 9052, Belgium.ORCID 0000-0002-5916-2587
Annica PreikschatInstitute of Immunology, University Medical Center of the Johannes-Gutenberg University, Mainz 55131, Germany.
David Gomez-ZepedaHelmholtz Institute for Translational Oncology Mainz (HI-TRON Mainz) - A Helmholtz Institute of the DKFZ, Mainz 55131, Germany.ORCID 0000-0002-9467-1213
Jeewan Babu RijalBioOrganic Mass Spectrometry Laboratory (LSMBO), IPHC UMR 7178, University of Strasbourg, CNRS, ProFI FR2048, Strasbourg 67087, France.ORCID 0009-0009-6839-9947
Aurélie HirschlerBioOrganic Mass Spectrometry Laboratory (LSMBO), IPHC UMR 7178, University of Strasbourg, CNRS, ProFI FR2048, Strasbourg 67087, France.ORCID 0000-0001-5066-6263
Jonathan R KriegerBruker Ltd., Milton, Ontario L9T 6P4, Canada.
Tharan SrikumarBruker Ltd., Milton, Ontario L9T 6P4, Canada.
George RosenbergerBruker Switzerland AG, Faellanden 8117, Switzerland.
Claudia MartelliBruker Switzerland AG, Faellanden 8117, Switzerland.
Dennis TredeBruker Daltonics GmbH & Co. KG, Bremen 28359, Germany.
Christine CarapitoBioOrganic Mass Spectrometry Laboratory (LSMBO), IPHC UMR 7178, University of Strasbourg, CNRS, ProFI FR2048, Strasbourg 67087, France.ORCID 0000-0002-0079-319X
Stefan TenzerInstitute of Immunology, University Medical Center of the Johannes-Gutenberg University, Mainz 55131, Germany.ORCID 0000-0003-3034-0017
Juliane S WalzDepartment of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen 72076, Germany.
Sven DegroeveVIB-UGent Center for Medical Biotechnology, VIB, Ghent 9052, Belgium.ORCID 0000-0001-8349-3370
Robbin BouwmeesterVIB-UGent Center for Medical Biotechnology, VIB, Ghent 9052, Belgium.ORCID 0000-0001-6807-7029
Lennart MartensVIB-UGent Center for Medical Biotechnology, VIB, Ghent 9052, Belgium.ORCID 0000-0003-4277-658X
Ralf GabrielsVIB-UGent Center for Medical Biotechnology, VIB, Ghent 9052, Belgium.ORCID 0000-0002-1679-1711

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The high throughput analysis of proteins with mass spectrometry (MS) is highly valuable for understanding human biology, discovering disease biomarkers, identifying therapeutic targets, and exploring pathogen interactions. To achieve these goals, specialized proteomics subfields, including plasma proteomics, immunopeptidomics, and metaproteomics, must tackle specific analytical challenges, such as an increased identification ambiguity compared to routine proteomics experiments. Technical advancements in MS instrumentation can mitigate these issues by acquiring more discerning information at higher sensitivity levels. This is exemplified by the incorporation of ion mobility and parallel accumulation and serial fragmentation (PASEF) technologies in timsTOF instruments. In addition, AI-based bioinformatics solutions can help overcome ambiguity issues by integrating more data into the identification workflow. Here, we introduce TIMS

Indexed as

Mass SpectrometryProteomicsSoftwareComputational BiologyDeep LearningHumansTandem Mass SpectrometryWorkflowDDA-PASEFmachine learningmass spectrometrypeptide identificationproteomicsrescoringtimsTOF

Identifiers

PMID39915959
PMCPMC11894666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.