Evidence map›Paper›PMID 39915894›Full record

ArticleVeterinary surgery : VS2025

Arthroscopic synovitis severity scoring in canine stifles with cranial cruciate ligament disease.

Elisabeth A Lemmon, Rui Xiao, Robert L Mauck, Kimberly A Agnello

Abstract readObservational Study, Veterinary
In one paragraph

Article in Veterinary surgery : VS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elisabeth A LemmonTranslational Musculoskeletal Research Center, CMC VA Medical Center, Philadelphia, Pennsylvania, USA.
Rui XiaoDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Robert L MauckTranslational Musculoskeletal Research Center, CMC VA Medical Center, Philadelphia, Pennsylvania, USA.
Kimberly A AgnelloTranslational Musculoskeletal Research Center, CMC VA Medical Center, Philadelphia, Pennsylvania, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007170 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BRASS, LAWRENCE F · 1985 to 2022
$54.0M
Dynamic Fibrous Scaffolds for Repairing Dense Connective TissuesR01AR056624 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Jason A Burdick, Robert L Mauck · 2009 to 2026
$7.5M
Companion Animal Research Fund, University of Pennsylvania CI150NIGMS NIH HHS T32 GM007170NIH HHS R01 AR056624NIH HHS T32 GM007170
6 · The paper itself

Abstract

objectiveTo investigate the occurrence, degree, and risk factors associated with arthroscopic stifle joint synovitis in dogs with cranial cruciate ligament (CCL) disease. STUDY

designRetrospective, observational study. SAMPLE POPULATION: Canine CCL disease (n = 163) from 149 dogs and their arthroscopic video recordings.

methodsArthroscopic video recordings were reviewed. A synovitis severity (0-5) and a modified Outerbridge cartilage classification system score were assigned, along with recording the presence or absence of a medial meniscal bucket handle tear. Medical records were reviewed for age, sex, limb, and duration of clinical signs. Univariate analyses were performed via a Fisher's exact test for categorical independent variables, and ordered logistic regression was used for continuous variables. Multivariable ordered logistic regression considered independent variables with a p-value <.2 on univariate analyses. p-value <.05 was considered statistically significant.

resultsSynovitis was identified in 100% of the stifles examined. The most frequent synovitis severity score was 3/5. Univariate analysis showed a significant association between synovitis severity score and bodyweight (p = .005), median cartilage score (p = .002), and being female (p = .032). On multivariable analysis, the synovitis severity score was significantly associated with median cartilage score (p = .042) and duration of clinical signs (p < .001).

conclusionSynovitis was arthroscopically always identified in stifles with CCL disease. The severity of synovitis was associated with more progressive damage to the articular cartilage and a longer duration of clinical signs. CLINICAL SIGNIFICANCE: Earlier intervention in dogs with CCL disease may be warranted to decrease synovitis and progression of osteoarthritis.

Indexed as

Anterior Cruciate LigamentAnterior Cruciate Ligament InjuriesArthroscopyDog DiseasesStifleSynovitisAnimalsDogsFemaleMaleRetrospective StudiesRisk FactorsSeverity of Illness Index

Identifiers

PMID39915894
PMCPMC11947301

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.