ArticleJournal of ovarian research2025
Maternal age-related declines in live birth rate following single euploid embryo transfer: a retrospective cohort study.
Article in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Maternal age as a driver of genome instability: mechanisms linking aneuploidy, mutagenesis and mitochondrial dysfunction.Archives of toxicology · 2026Review
- Review
- Aging Regulates Receptivity by Modulating the Expression of Osteopontin and HOXA10 in the Human Endometrium.Journal of clinical medicine · 2026Article
- Single vs. double good-quality embryo transfer in fresh cleavage-stage cycles: a propensity score-matched analysis of efficacy and risks.Journal of ovarian research · 2026Article
- Effect of basal LH levels on pregnancy outcome after IVF/ICSI fresh embryo transfer in patients of different ages: a retrospective study.Frontiers in endocrinology · 2026Article
- The immune microenvironment: a key regulator of ovarian function during ovarian aging.Frontiers in immunology · 2026Review
- Comparison of pregnancy outcomes in uterine fibroids following high intensity focused ultrasound ablation vs. laparoscopic myomectomy: a propensity score-matched observational study.Frontiers in surgery · 2026Article
- Analysis of related factors of biochemical pregnancy loss in single blastocyst transfer in the hormone replacement protocol frozen-thawed cycle.BMC pregnancy and childbirth · 2025Article
- Number of top-quality embryos transferred has no advantage in women over the age of 40 in FET cycles.BMC pregnancy and childbirth · 2025Article
- Spontaneous ovulation, hormonal profiles, and the impact of progesterone timing variation on outcomes in natural proliferative phase frozen embryo transfer cycles with single euploid blastocyst transfer.Journal of ovarian research · 2025Article
- The Possibility and Characteristics of Senescence-Related Changes in Reproductive Tissues Such as the Ovary, Oviduct, and Uterus.Reproductive medicine and biologyReview
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9 authors.
Funding
Abstract
purposeTo assess whether maternal age influences the pregnancy outcomes after single frozen euploid embryo transfer.
methodsThis retrospective analysis was conducted on 1037 cycles of single euploid embryo transfer performed at Nanjing Women and Children's Healthcare Hospital between January 2016 and April 2023. Patients with severe uterine pathologies, immune disorders, or endocrine diseases were excluded. The cycles were categorized into three age groups: <35 years, 35-37 years, and ≥ 38 years. Primary outcomes included live birth rate, clinical pregnancy rate, early pregnancy loss, and miscarriage rate. Data were analyzed using multivariable logistic regression with generalized estimating equations (GEE) to account for confounding factors and restricted cubic splines to visualize the relationship between maternal age and pregnancy outcomes.
resultsWomen aged ≥ 38 years demonstrated a significantly diminished live birth rate (41.7%) ,which was lower than that observed in women aged < 35 years (54.5%) and 35-37 years (54.0%), with statistical significance (P < 0.05). Multivariable regression analysis revealed that compared with women aged ≥ 38 years, younger women had reduced risk of miscarriage (aOR = 0.371, 95% CI: 0.139-0.988 for the < 35 years group; aOR = 0.317, 95% CI: 0.106-0.954 for the 35-37 years group) and increased likelihood of live birth (aOR = 2.188, 95% CI: 1.154-4.147 for the < 35 years group; aOR = 2.239, 95% CI: 1.0103-4.548 for the 35-37 years group) after adjusting for relevant confounders. Additionally, the analysis showed that embryos biopsied on day 5 were linked to higher clinical pregnancy rates than those biopsied on day 6, and high-grade blastocysts were associated with superior pregnancy outcomes.
conclusionAdvanced maternal age is associated with a higher miscarriage rate and lower live birth rate following euploid embryo transfer. Despite the exclusion of aneuploidy, age-related factors beyond chromosomal abnormalities appear to impact reproductive outcomes.
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