ArticleBMC medicine2025
Anxiety disorder, depression and coronary artery disease: associations and modification by genetic susceptibility.
Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Seasonality of Cytokines in Inflammatory Disease: Exploring Molecular Parallels with the Yellow Emperor's Inner Canon.Biology · 2026Review
- Association Between Metabolic Syndrome and Psychiatric Morbidity in a Nationwide Taiwanese Population Study.Nutrients · 2026Article
- Shifts in socioeconomic status alter cardiovascular disease risk and mortality through modulating Life's Crucial 9: a prospective cohort study of UK Biobank participants.BMJ public health · 2026Article
- Exploring Factors Affecting Health-Related Quality of Life in Coronary Artery Disease Patients.Medicina (Kaunas, Lithuania) · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundAssociations of anxiety disorder and depression with coronary artery disease (CAD) are heterogeneous between populations. This study investigated how genetic susceptibility to CAD alters these associations with incident CAD, comparing and combining anxiety disorder and depression.
methodsThis is a prospective cohort study using UK Biobank. Diagnoses of anxiety disorder and depression were ascertained through linked hospital admission data. Incident CAD was ascertained through hospital admission and death certificate data after baseline. CAD polygenic risk score (PRS
resultsBoth anxiety disorder (HR 2.31, 95% CI 1.92-2.78) and depression (HR 2.15, 95% CI 1.90-2.24) were associated with CAD after adjusting for sociodemographic confounders. There was an addictive interaction between depression and PRS
conclusionsCAD genetic susceptibility might partly contribute to the clustering of depression and CAD but does not provide a full explanation, nor does it explain the association between anxiety disorder and CAD. Therefore, other mechanisms should be explored.
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