Evidence map›Paper›PMID 39915847›Full record

SynthesisBMC musculoskeletal disorders2025

Prevention and management of degenerative lumbar spine disorders through artificial intelligence-based decision support systems: a systematic review.

Paolo Giaccone, Federico D'Antoni, Fabrizio Russo, Luca Ambrosio, Giuseppe Francesco Papalia, Onorato d'Angelis, Gianluca Vadalà, Albert Comelli, Luca Vollero, Mario Merone and 2 more

Abstract readSystematic Review
In one paragraph

Synthesis in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Paolo GiacconeFondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, Rome, 00128, Italy.
Federico D'AntoniFondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, Rome, 00128, Italy. f.dantoni@unicampus.it.
Fabrizio RussoOperative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, Rome, 00128, Italy. fabrizio.russo@policlinicocampus.it.
Luca AmbrosioOperative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, Rome, 00128, Italy.
Giuseppe Francesco PapaliaOperative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, Rome, 00128, Italy.
Onorato d'AngelisResearch Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, Rome, 00128, Italy.
Gianluca VadalàOperative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, Rome, 00128, Italy.
Albert ComelliRi.MED Foundation, Via Bandiera, 11, Palermo, 90133, Italy.
Luca VolleroResearch Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, Rome, 00128, Italy.
Mario MeroneResearch Unit of Intelligent Technology for Health and Wellbeing, Department of Engineering, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, Rome, 00128, Italy.
Rocco PapaliaOperative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, Rome, 00128, Italy.
Vincenzo DenaroOperative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, Rome, 00128, Italy.

Funding

Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro BRIC-2022 ID28 - ID30NextGenerationEU NRRP M6C2 - Investment 2.1 Enhancement and strengthening of biomedical research in the NHS, project n. PNRR-MAD-2022-12376692 VADALA
6 · The paper itself

Abstract

backgroundLow back pain is the leading cause of disability worldwide with a significant socioeconomic burden; artificial intelligence (AI) has proved to have a great potential in supporting clinical decisions at each stage of the healthcare process. In this article, we have systematically reviewed the available literature on the applications of AI-based Decision Support Systems (DSS) in the clinical prevention and management of Low Back Pain (LBP) due to lumbar degenerative spine disorders.

methodsA systematic review of Pubmed and Scopus databases was performed according to the PRISMA statement. Studies reporting the application of DSS to support the prevention and/or management of LBP due to lumbar degenerative diseases were included. The QUADAS-2 tool was utilized to assess the risk of bias in the included studies. The area under the curve (AUC) and accuracy were assessed for each study.

resultsTwenty five articles met the inclusion criteria. Several different machine learning and deep learning algorithms were employed, and their predictive ability on clinical, demographic, psychosocial, and imaging data was assessed. The included studies mainly encompassed three tasks: clinical score definition, clinical assessment, and eligibility prediction and reached AUC scores of 0.93, 0.99 and 0.95, respectively.

conclusionsAI-based DSS applications showed a high degree of accuracy in performing a wide set of different tasks. These findings lay the foundation for further research to improve the current understanding and encourage wider adoption of AI in clinical decision-making.

Indexed as

Artificial IntelligenceDecision Support Systems, ClinicalIntervertebral Disc DegenerationLow Back PainLumbar VertebraeClinical Decision-MakingHumansArtificial intelligenceDecision support systemDeep learningIntervertebral discLow back painMachine learningPreventionSpine

Identifiers

PMID39915847
PMCPMC11803955

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.