Evidence map›Paper›PMID 39915845›Full record

ArticleCardio-oncology (London, England)2025

Major adverse cardiovascular events among Black and White Veterans receiving androgen deprivation therapy for prostate cancer: a retrospective cohort study.

Alexander R Lucas, Dustin Bastiach, Bassam Dahman, Asit K Paul, Samina Hirani, Vanessa B Sheppard, W Gregory Hundley, Bhaumik B Patel, Rhonda L Bitting, Michael G Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardio-oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander R LucasDepartment of Social and Behavioral Sciences, Virginia Commonwealth University School of Public Health, One Capitol Square, 830 East Main Street, Richmond, VA, USA. Alexander.Lucas@vcuhealth.org.
Dustin BastiachDepartment of Biostatistics, Virginia Commonwealth University School of Public Health, Richmond, VA, USA.
Bassam DahmanDivision of Cardiology, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Asit K PaulDivision of Hematology and Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Samina HiraniDivision of Hematology and Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Vanessa B SheppardDivision of Cardiology, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
W Gregory HundleyDivision of Cardiology, VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Bhaumik B PatelDivision of Hematology and Oncology, Department of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Rhonda L BittingDivision of Medical Oncology, Department of Medicine, Duke University and Durham VA Healthcare System, Durham, NC, USA.
Michael G ChangDepartment of Radiation Oncology, Massey Cancer Center, Virginia Commonwealth University Health System, Richmond, VA, USA.

Funding

Behavioral Exercise Training to Reduce Cardiovascular Disease Risk in Men Undergoing Androgen Deprivation TherapyK01HL161419 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Alexander Russell Lucas · 2023 to 2026
$496k
Division of Cancer Prevention, National Cancer Institute NCORP-GY10NHLBI NIH HHS 1K01HL161419NHLBI NIH HHS K01 HL161419
6 · The paper itself

Abstract

backgroundAndrogen deprivation therapy (ADT) is the cornerstone treatment strategy for men diagnosed with high-risk prostate cancer (PC) but may increase risk for major adverse cardiovascular events (MACE). We examined whether men treated with ADT and radiation therapy (ADT + RT) developed MACE at a higher rate than men receiving RT alone. Secondly, we sought to determine if Black men receiving RT + ADT developed MACE at a higher rate than White men.

methodsThis retrospective cohort study examined time to diagnosis of MACE among Veterans with PC. We used a 1:1 propensity score matching process to determine whether treatment type (ADT + RT vs. RT alone), race (Black vs. White men) or having a previous diagnosis of a cardiometabolic disease (CMD) were associated with differences in the rate at which men develop MACE.

resultsVeterans with PC were White (68%) and Black (32%). At PC diagnosis, the mean age was 65.9 years. The majority had stage 2 disease (83.0%) classified as intermediate risk (43.1%). Treatment-matched models showed men receiving ADT + RT were less likely to develop MACE when they no pre-existing CMD. Men treated with ADT + RT or RT alone had significantly increased risks of MACE is they had pre-existing CMD. Black men had the same risk of MACE as non-Hispanic Whites.

conclusionsPreexisting CMD and multimorbidity are significant risks for MACE among men treated for PC within the VA healthcare system whether treated with ADT + RT or with RT alone, highlighting the importance pretreatment optimization of comorbidities.

Indexed as

Androgen deprivation therapyCardiometabolic diseaseMajor adverse cardiovascular eventsProstate cancerSurvivorshipVeterans

Identifiers

PMID39915845
PMCPMC11800468

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.