ArticleJournal of intensive care2025
Two-year trajectory of functional recovery and quality of life in post-intensive care syndrome: a multicenter prospective observational study on mechanically ventilated patients with coronavirus disease-19.
Article in Journal of intensive care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Health-related quality of life in COVID-19 patients: a systematic review and meta-analysis of EQ-5D studies.Health and quality of life outcomes · 2025Pooled it
- Distinct Health-Related Quality of Life Recovery Trajectories Among ICU Survivors: A Multicentre Prospective Cohort Study Using the EQ-5D-5L.Nursing in critical care · 2026Observational
- Three-year functional, physical, and mental health outcomes after critical COVID-19: A prospective multicentre cohort study.PloS one · 2026Article
- Latent Classes in Long-Term Functional Status in Children With Recurrent Critical Illness.Critical care medicine · 2026Article
- APACHE II and NUTRIC Scores for Mortality Prediction in Chronic Critical Illness: A "Right-Side" Prognostic Modeling Approach.Diagnostics (Basel, Switzerland) · 2025Article
- Long-term recovery of sensorimotor functions and prediction of participation in survivors of critical illness: a prospective cohort study.Journal of intensive care · 2025Article
- Factors Associated with Post-Intensive Care Syndrome in Patients Attending a Hospital in Northern Colombia: A Quantitative and Correlational Study.Nursing reports (Pavia, Italy) · 2025Article
- Translation and validation of the Chinese version of the post-intensive care syndrome questionnaire.BMC nursing · 2025Article
- Review
- Effects of Long COVID in Patients with Severe Coronavirus Disease 2019 on Long-Term Functional Impairments: A Post Hoc Analysis Focusing on Patients Admitted to the ICU in the COVID-19 Recovery Study II.Healthcare (Basel, Switzerland) · 2025Article
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39 authors.
Funding
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Abstract
backgroundPost-intensive care syndrome (PICS) affects the quality of life (QOL) of survivors of critical illness. Although PICS persists for a long time, the longitudinal changes in each component and their interrelationships over time both remain unclear. This multicenter prospective study investigated the 2-year trajectory of PICS and its components as well as factors contributing to deterioration or recovery in mechanically ventilated patients with coronavirus disease 2019 (COVID-19), and also attempted to identify possible countermeasures.
methodsPatients who survived COVID-19 requiring mechanical ventilation completed questionnaires on the Barthel index, Short-Memory Questionnaire, Hospital Anxiety and Depression Scale, and EuroQol 5 dimensions 5-level every six months over a two-year period. Scores were weighted to account for dropouts, and the trajectory of each functional impairment was evaluated with alluvial diagrams. The prevalence of PICS and factors impairing or restoring function were examined using generalized estimating equations considering trajectories.
resultsAmong 334 patients, PICS prevalence rates in the four completed questionnaires were 72.1, 78.5, 77.6, and 82.0%, with cognitive impairment being the most common and lower QOL being noted when multiple impairments coexisted. Physical function and QOL indicated that many patients exhibited consistent trends of either recovery or deterioration. In contrast, cognitive function and mental health revealed considerable variability, with many patients showing fluctuating ratings in the later surveys. Delirium was associated with worse physical and mental health and poor QOL, while prolonged ventilation was associated with poor QOL. Living with family was associated with the recovery of all functions and QOL, while extracorporeal membrane oxygenation (ECMO) was associated with the recovery of cognitive function and mental health.
conclusionsCritically ill patients had PICS for a long period and followed different trajectories for each impairment component. Based on trajectories, known PICS risk factors such as prolonged ventilation and delirium were associated with impaired recovery, while ECMO and the presence of family were associated with recovery from PICS. In critically ill COVID-19 patients, delirium management and family interventions may play an important role in promoting recovery from PICS. TRIAL REGISTRATION NUMBER: UMIN000041276, August 01, 2020.
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