Evidence map›Paper›PMID 39915752›Full record

ArticleBMC gastroenterology2025

Clinical risk factors for sarcopenia in acute and chronic pancreatitis.

Mitchell L Ramsey, Andrew Lu, Kristyn Gumpper-Fedus, Stacey Culp, David Bradley, Darwin L Conwell, Zobeida Cruz-Monserrate, J Royce Groce, Samuel Han, Somashekar G Krishna and 6 more

Abstract read
In one paragraph

Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mitchell L RamseyDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH, 43210, USA. Mitchell.Ramsey@osumc.edu.
Andrew LuDepartment of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Kristyn Gumpper-FedusDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH, 43210, USA.
Stacey CulpDepartment of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, OH, USA.
David BradleyDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.
Darwin L ConwellDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH, 43210, USA.
Zobeida Cruz-MonserrateDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH, 43210, USA.
J Royce GroceDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH, 43210, USA.
Samuel HanDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH, 43210, USA.
Somashekar G KrishnaDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH, 43210, USA.
Peter LeeDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH, 43210, USA.
Thomas MaceDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH, 43210, USA.
Georgios I PapachristouDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH, 43210, USA.
Kristen M RobertsDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH, 43210, USA.
Zarine K ShahDepartment of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Phil A HartDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH, 43210, USA.

Funding

The Ohio State University Pancreatic Disorders Network (OSU-PDN)U01DK108327 · NIDDK · OHIO STATE UNIVERSITY · PI CONWELL, DARWIN LEWIS, HART, PHILIP A. · 2015 to 2024
$5.5M
NIDDK NIH HHS U01 DK108327NIDDK NIH HHS U01DK108327
6 · The paper itself

Abstract

backgroundSarcopenia is common in chronic pancreatitis (CP) and has been associated with unfavorable outcomes; however, it is not well studied in acute pancreatitis (AP).

aimsTo evaluate risk factors for sarcopenia among individuals with AP or CP.

methodsA cross sectional analysis was performed among subjects with AP or CP seen in a tertiary care Pancreas Clinic. TeraRecon software was used to calculate the cross-sectional area of skeletal muscle, visceral fat, and subcutaneous fat at the level of the L3 vertebrae. Sarcopenia was classified using sex-specific skeletal muscle index. Univariate and multivariate logistic regressions were performed to assess differences between groups and associations with sarcopenia.

resultsA total of 49 subjects with AP and 54 subjects with CP were included. Sarcopenia was more frequently observed in CP compared to AP (83.3% vs. 46.9%, p < 0.001). The multivariate logistic regression demonstrated CP, male sex, increased age, and decreased subcutaneous fat were independently associated with sarcopenia.

conclusionSarcopenia is observed in both CP and AP. In addition to traditional risk factors (including male sex, older age, and decreased subcutaneous fat), CP is independently associated with sarcopenia. Further investigations are necessary to gain deeper insights into sarcopenia pathogenesis, which could inform potential intervention strategies.

Indexed as

PancreatitisPancreatitis, ChronicSarcopeniaAcute DiseaseAdultAgedAge FactorsCross-Sectional StudiesFemaleHumansIntra-Abdominal FatLogistic ModelsMaleMiddle AgedMuscle, SkeletalRisk FactorsBody compositionSarcopeniaSkeletal muscleSubcutaneous fatVisceral fat

Identifiers

PMID39915752
PMCPMC11800437

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.