Evidence map›Paper›PMID 39915714›Full record

ArticleBMC anesthesiology2025

Application of a novel extracorporeal membrane oxygenation system in awake Hu sheep under various durations.

Shuo Ding, Juan Chen, Yanchao Wu, Huiru Lin, Qiqiang Liang, Gaoqin Teng, Zhenjie Liu, Man Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuo DingDepartment of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang, University School of Medicine, Hangzhou, Zhejiang, P. R. China.
Juan ChenDepartment of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang, University School of Medicine, Hangzhou, Zhejiang, P. R. China.
Yanchao WuDepartment of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang, University School of Medicine, Hangzhou, Zhejiang, P. R. China.
Huiru LinDepartment of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang, University School of Medicine, Hangzhou, Zhejiang, P. R. China.
Qiqiang LiangDepartment of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang, University School of Medicine, Hangzhou, Zhejiang, P. R. China.
Gaoqin TengDepartment of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang, University School of Medicine, Hangzhou, Zhejiang, P. R. China.
Zhenjie LiuDepartment of Vascular Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China.
Man HuangDepartment of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang, University School of Medicine, Hangzhou, Zhejiang, P. R. China. huangman@zju.edu.cn.

Funding

Leading Talents Program of Zhejiang Province 2024C03185
6 · The paper itself

Abstract

backgroundExtracorporeal membrane oxygenation (ECMO) provides effective support for respiratory and circulatory functions and stands as an essential means in the management of life-threatening conditions. This study aimed to evaluate the safety and efficacy of a novel ECMO system in awake sheep models across various support durations.

methodsTen healthy Hu sheep were divided into venovenous (VV) and venoarterial (VA) groups, further categorized into short, medium, and long-term observation subgroups. Vital signs and blood indices were meticulously monitored. The integrity of heparin coatings and thrombosis in the ECMO system were assessed at indicated time points, followed by histopathological analysis.

resultsAll ten sheep survived to their planned endpoints under awake ECMO, exhibiting stable vital signs without notable reductions in blood cells. With the support of ECMO, all sheep demonstrated a significant increase in partial pressure of oxygen (PO

conclusionsIn healthy Hu sheep models with different maintenance periods, the novel ECMO support in awake state demonstrated high safety and feasibility.

Indexed as

Extracorporeal Membrane OxygenationWakefulnessAnimalsFemaleHeparinOxygenSheepTime FactorsHeparinOxygenAwake ECMOCardiopulmonary supportECMOExtracorporeal membrane oxygenationOvine modelPreclinical evaluation

Identifiers

PMID39915714
PMCPMC11800640

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.