Evidence map›Paper›PMID 39915702›Full record

SynthesisBMC anesthesiology2025

Impact of a positive end-expiratory pressure on oxygenation, respiratory compliance, and hemodynamics in obese patients undergoing laparoscopic surgery in reverse Trendelenburg position: a systematic review and meta-analysis of randomized controlled trials.

Gulfairus A Yessenbayeva, Aizhan M Meyerbekova, Sergey I Kim, Murat B Zhumabayev, Gulbanu S Berdiyarova, Sanzhar B Shalekenov, Dinara S Zharlyganova, Irina Y Mukatova, Yekaterina A Yukhnevich, Dmitriy A Klyuyev and 1 more

Registry-linked trialAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07462689 (Comparison of Positive End-expiratory Pressure and Alveolar Recruitment Maneuver on Perioperative Oxygenation in Patients Undergoing Robotic Radical Prostatectomy), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07462689 nacompletednot on this map

Comparison of Positive End-expiratory Pressure and Alveolar Recruitment Maneuver on Perioperative Oxygenation in Patients Undergoing Robotic Radical Prostatectomy: a Randomized Controlled Trial

TypeinterventionalSponsorIlsan Cha hospitalRan2020 to 2024Enrolled58ConditionsRobot-Assisted Radical ProstatectomyArmsPEEP group, PEEP + ARM group
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gulfairus A YessenbayevaNational Research Oncology Center, Astana, Kazakhstan.ORCID 0000-0001-7841-1801
Aizhan M MeyerbekovaNazarbayev University, Astana, Kazakhstan.ORCID 0009-0001-8260-913X
Sergey I KimMultidisciplinary Hospitals Named After Professor H.J.Makazhanov, Karaganda, Kazakhstan.ORCID 0009-0003-4111-5517
Murat B ZhumabayevAstana Medical University, Astana, Kazakhstan.ORCID 0000-0002-2405-4447
Gulbanu S BerdiyarovaKazakhstan Medical University "Higher School of Health Care Organization", Almaty, Kazakhstan.ORCID 0000-0003-2556-5123
Sanzhar B ShalekenovNational Research Oncology Center, Astana, Kazakhstan.ORCID 0000-0003-3400-9823
Dinara S ZharlyganovaNational Research Oncology Center, Astana, Kazakhstan.ORCID 0000-0001-6383-4035
Irina Y MukatovaAstana Medical University, Astana, Kazakhstan.ORCID 0000-0002-5804-8643
Yekaterina A YukhnevichKaraganda Medical University, Karaganda, Kazakhstan.ORCID 0000-0001-5992-0336
Dmitriy A KlyuyevKaraganda Medical University, Karaganda, Kazakhstan.ORCID 0000-0003-2012-2227
Andrey I YaroshetskiySechenov First Moscow State Medical University (Sechenov University), Moscow, Russia. dr.intensivist@gmail.com.ORCID 0000-0002-1484-092X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh and individual positive end-expiratory pressure (PEEP) during laparoscopic surgery may improve oxygenation and respiratory mechanics.

methodsWe searched RCTs in PubMed, Cochrane Library, Web of Science, and Google Scholar from from from January 2000 to December 2023 comparing the different intraoperative PEEP (low PEEP (LPEEP): 0-5 mbar; moderate PEEP (MPEEP): 6-9 mbar; high PEEP (HPEEP): >=10 mbar; individualized PEEP (iPEEP): PEEP set by special physiological technique) on arterial oxygenation, respiratory compliance (Cdyn) or driving pressure, mean arterial pressure (MAP), and heart rate (HR) in patients during laparoscopic surgery in reverse Trendelenburg position. We calculated mean differences (MD) with 95% confidence intervals (CI), and predictive intervals (PI) using random-effects models. The Cochrane Bias Risk Assessment Tool was applied.

results8 RCTs (n = 425) met the inclusion criteria. HPEEP vs. LPEEP increased PaO

conclusionIn patients with obesity undergoing surgery in the reverse Trendelenburg position HPEEP and iPEEP may improve oxygenation, decrease driving pressure, and increase dynamic compliance compared to LPEEP with high variation of true effect without relevant hemodynamic compromise. Data with MPEEP comparisons are inconclusive. PROSPERO REGISTRATION: CRD42023488971; registered December 14, 2023.

Indexed as

Head-Down TiltHemodynamicsLaparoscopyObesityOxygenPositive-Pressure RespirationHumansLung ComplianceRandomized Controlled Trials as TopicOxygenComplianceLaparoscopic surgeryLung protective ventilationMeta-analysisObeseObesityOxygenationPEEPPneumoperitoneumPositive end-expiratory pressure

Identifiers

PMID39915702
PMCPMC11803948

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.