Evidence map›Paper›PMID 39915643›Full record

ArticleNPJ digital medicine2025

Challenges with reinforcement learning model transportability for sepsis treatment in emergency care.

Peter C Nauka, Jason N Kennedy, Emily B Brant, Matthieu Komorowski, Romain Pirracchio, Derek C Angus, Christopher W Seymour

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peter C NaukaDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Jason N KennedyDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Emily B BrantDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Matthieu KomorowskiDepartment of Surgery and Cancer, Imperial College London, London, UK.
Romain PirracchioDepartment of Anesthesia and Perioperative Medicine, Zuckerberg San Francisco General Hospital and Trauma Center, University of California San Francisco, San Francisco, CA, USA.
Derek C AngusDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Christopher W SeymourDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. seymourcw@upmc.edu.

Funding

Sepsis subtypes: biology, treatment, and bedside applicationR35GM119519 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Christopher W. Seymour · 2016 to 2026
$4.9M
NIGMS NIH HHS R35 GM119519NIH HHS R35GM119519
6 · The paper itself

Abstract

Pivotal moments in sepsis care occur in the emergency department (ED), however, and it is unclear whether ED data is adequate to inform reinforcement learning (RL) models. We evaluated the early opportunity for the AI Clinician, a validated ICU-based RL-model, as a use case. Amongst emergency sepsis patients, model parameters were often missing and invariably measured. Current iterations of RL-models trained on ICU data face challenges in emergency sepsis care.

Identifiers

PMID39915643
PMCPMC11802805

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.