ArticleScientific reports2025
Age-related thinning of orbicularis oculi muscle inside upper eyelid and its possible association with sunken upper eyelids.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The Anatomy of Facial Muscles Revisited: High-Resolution Magnetic Resonance Imaging and Computed Tomography Studies on Body Donors.Journal of imaging · 2026Article
- Multimodal Management of Sunken Upper Eyelid: A Retrospective Study of 94 Cases Focusing on Orbital Septal Fat Deficiency, Autologous Fat Transplantation, and Simultaneous Correction of Comorbidities.Aesthetic plastic surgery · 2026Article
- A computer vision-based framework for objective evaluation of sunken upper eyelid.Scientific reports · 2025Article
- Applications of Magnetic Resonance Imaging in Upper Eyelid Anatomy and Upper Eyelid Blepharoplasty: A Systematic Review.Plastic and reconstructive surgery. Global open · 2025Article
- Evaluation of morphological and psychological outcomes after sub-brow blepharoplasty.Frontiers in surgery · 2025Article
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Authors and funding
5 authors.
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Abstract
Sunken upper eyelid is a morphological symptom that surrounds the eye with aging; however, its causes remain poorly understood. We investigated the correlations between the sunken upper eyelid and morphological parameters inside the eye area using magnetic resonance imaging (MRI), verified the relationship between age and degree of sunken upper eyelid photographically, and quantified muscle fibers histologically classified by myosin heavy chain (MYH) species and connective tissues in the superior palpebral part of the orbicularis oculi muscle from cadaveric specimens of various ages. The results showed the development of sunken upper eyelids, decreased thickness and number of MYH4-positive muscle fibers, and increased collagen and elastic fiber proportions in the orbicularis oculi muscle with age. On MRI, both the thickness of the orbicularis oculi muscle and the vertical position of the globe within the orbit were negatively correlated with the sunken upper eyelid. Changes in the orbicularis oculi muscle offer new insights into the mechanisms underlying age-related morphological changes in the periocular area.
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