Evidence map›Paper›PMID 39915633›Full record

ArticleNPJ digital medicine2025

Real world federated learning with a knowledge distilled transformer for cardiac CT imaging.

Malte Tölle, Philipp Garthe, Clemens Scherer, Jan Moritz Seliger, Andreas Leha, Nina Krüger, Stefan Simm, Simon Martin, Sebastian Eble, Halvar Kelm and 15 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Multi-modal dataset creation for federated learning with DICOM-structured reports.International journal of computer assisted radiology and surgery · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Malte TölleDZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany. malte.toelle@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-0804-5794
Philipp GartheClinic for Cardiology III, University Hospital Münster, Münster, Germany.
Clemens SchererDZHK (German Centre for Cardiovascular Research), partner site Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-2816-6793
Jan Moritz SeligerDZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.
Andreas LehaDZHK (German Centre for Cardiovascular Research), partner site Lower Saxony, Göttingen, Germany.ORCID http://orcid.org/0000-0002-8072-1988
Nina KrügerDZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Stefan SimmDZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0001-9371-2709
Simon MartinDZHK (German Centre for Cardiovascular Research), partner site RhineMain, Frankfurt, Germany.
Sebastian EbleDepartment of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.
Halvar KelmDepartment of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.
Moritz BednorzDepartment of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-4981-5732
Florian AndréDZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany.
Peter BannasDZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.ORCID http://orcid.org/0000-0002-7102-534X
Gerhard DillerClinic for Cardiology III, University Hospital Münster, Münster, Germany.
Norbert FreyDZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany.
Stefan GroßDZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-4121-7161
Anja HennemuthDZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-0737-7375
Lars KaderaliDZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-2359-2294
Alexander MeyerDZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Eike NagelDZHK (German Centre for Cardiovascular Research), partner site RhineMain, Frankfurt, Germany.
Stefan OrwatClinic for Cardiology III, University Hospital Münster, Münster, Germany.
Moritz SeiffertDZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.
Tim FriedeDZHK (German Centre for Cardiovascular Research), partner site Lower Saxony, Göttingen, Germany.ORCID http://orcid.org/0000-0001-5347-7441
Tim SeidlerDZHK (German Centre for Cardiovascular Research), partner site Lower Saxony, Göttingen, Germany.
Sandy EngelhardtDZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Federated learning is a renowned technique for utilizing decentralized data while preserving privacy. However, real-world applications often face challenges like partially labeled datasets, where only a few locations have certain expert annotations, leaving large portions of unlabeled data unused. Leveraging these could enhance transformer architectures' ability in regimes with small and diversely annotated sets. We conduct the largest federated cardiac CT analysis to date (n = 8, 104) in a real-world setting across eight hospitals. Our two-step semi-supervised strategy distills knowledge from task-specific CNNs into a transformer. First, CNNs predict on unlabeled data per label type and then the transformer learns from these predictions with label-specific heads. This improves predictive accuracy and enables simultaneous learning of all partial labels across the federation, and outperforms UNet-based models in generalizability on downstream tasks. Code and model weights are made openly available for leveraging future cardiac CT analysis.

Identifiers

PMID39915633
PMCPMC11802793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.