ArticlePediatric research2025
Physiological and lifestyle determinants of bone mass in minority children/adolescents from the MetA-Bone Trial.
Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAdolescence leads to enormous skeletal growth. Therefore, understanding predictors of bone mass in this period is paramount to prevent future fractures/osteoporosis.
methodsThis was a cross-sectional secondary analysis of the baseline visit of children/adolescents from the MetA-Bone Trial to evaluate the physiological (age, maturity stage, body composition) and lifestyle (diet, physical activity, stress, and sleep) determinants of whole-body and lumbar spine bone mineral content (BMC) and density (BMD).
resultsIn this sample of 213 predominantly Hispanic boys and girls, we found sex similarities and differences in the predictors of bone mass. Lean mass was a significant positive predictor across all bone outcomes in both boys and girls. In boys, BMI percentile was a negative predictor of lumbar spine BMC (B = -0.035, p = 0.030) while sleep duration was a significant positive predictor of whole-body BMC (B = 8.7, p = 0.036). In girls, physical activity was a significant positive predictor of whole-body BMD (B = 2950-E-5, p = 0.029). The other variables studied were not significant predictors of bone mass in this sample.
conclusionThere were important determinants of bone mass in this sample, but longitudinal studies are needed to understand their role in bone mass acquisition during puberty. IMPACT: Physiological and lifestyle determinants of bone mass in this sample of predominately Hispanic children and adolescents were mainly lean mass. Self-reported race, ethnicity, family history of osteoporosis, diet quality (HEI-2020), and stress did not significantly predict bone mass in this sample. Identifying physiological and novel modifiable lifestyle factors to maximize bone mass acquisition in Hispanic children and adolescents is paramount to designing targeted interventions to promote long-term bone health and quality of life.
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