ArticlePediatric research2025
Detection of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia using oxygen saturation data.
Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Impact of pulmonary hypertension on long-term neurodevelopmental outcomes in preterm neonates with bronchopulmonary dysplasia: A meta-analysis.Pakistan journal of medical sciences · 2026Review
- Leveraging oxygen saturation monitoring for improved detection of pulmonary hypertension in preterm infants.Pediatric research · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundPulmonary hypertension (PH) complicates the clinical course of bronchopulmonary dysplasia (BPD) in preterm infants, increasing risk of mortality and other morbidities. Early detection of PH may provide the clinical opportunity for earlier initiation of PH targeted therapies.
methodsWe analyzed variability patterns of oxygen saturation data in 41 preterm infants with BPD and associated PH and 57 infants with BPD alone using irregularity indices to identify PH. Irregularity of oxygen saturation (SpO
resultsSpO
conclusionIrregularity profiles of oxygen saturation variability are distinct in infants with BPD and PH. Signal based measures derived from routinely collected SpO IMPACT: Early detection of pulmonary hypertension (PH) may improve outcomes in infants with bronchopulmonary dysplasia (BPD). Bedside markers which can track evolving PH, using routinely collected data in the NICU are hence important. Analysis of the irregularity exhibited by oxygen saturation variability data from preterm infants with BPD identified distinctive behavior in the presence of PH. We demonstrated detection of PH using signal measures accounting for known clinical risk factors using data acquired prior to clinical diagnosis. This study expands the possibility of implementing signal based models for early identification of PH in this vulnerable population.
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