ArticleNature communications2025
Triglyceride levels and its association with all-cause mortality and cardiovascular outcomes among patients with heart failure.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Beyond LDL-C: Modern Lipid Management for ASCVD Prevention in Primary Care.Cardiology and therapy · 2026Review
- Hypertriglyceridemia predicts good neurological outcome after mechanical thrombectomy in patients with acute ischemic stroke due to large-vessel disease.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2026Article
- Triglyceride-Rich Lipoproteins and Inflammation: Independent and Synergistic Roles in Cardiovascular Disease.Current atherosclerosis reports · 2026Review
- Systems genomics reveals age- and sex-dependent metabolic dysregulation fromPhysiological genomics · 2026Article
- [The association between serum triglycerides and colorectal cancer incidence in community-dwelling middle-aged and older adults in Korea: a secondary analysis of a community-based prospective cohort].Journal of Korean biological nursing science · 2026Article
- Triglyceride levels and all-cause mortality in patients with left main coronary artery disease undergoing percutaneous coronary intervention.Frontiers in cardiovascular medicine · 2026Article
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- Metabolic syndrome and risk of sepsis and sepsis-related mortality: evidence from two large prospective cohort studies.Military Medical Research · 2026Article
- Dual clinical utility of cholesterol, high density lipoprotein, and glucose index: from advanced cardiovascular-kidney-metabolic syndrome pathogenesis to inflammatory-mediated mortality across early-transitional stages.Diabetology & metabolic syndrome · 2025Article
- Clinical study on the relationship between exposure to ultrafine particles (PMToxicology reports · 2025Article
- Associations of the Zhejiang University (ZJU) index with cardiovascular diseases and mortality among US adults: a national cohort study.Lipids in health and disease · 2025Article
- Article
- Prolonged Exposure to Antiretroviral Therapy and Risk of Developing Hypertension Among HIV-Infected Clinic Attendees: A Pilot Study in Rural Eastern Cape Province, South Africa.International journal of environmental research and public health · 2025Article
- Association of lipid accumulation product with mortality in patients with diabetes mellitus.Scientific reports · 2025Article
- Spatial analysis of air pollutant exposure and its association with metabolic diseases using machine learning.BMC public health · 2025Article
- Predictive value of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) for all-cause and cardiovascular mortality with non-hyperhomocysteinemia: evidence from NHANES 1999 to 2006.Frontiers in nutrition · 2025Article
- Hypertriglyceridemia as an independent predictor of adverse prognosis in female patients with acute myocardial infarction: a comprehensive retrospective cohort study.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Remnant cholesterol, identified by triglyceride-rich lipoprotein, is a significant causal risk factor for ischemic heart diseases. The association of triglyceride levels with all-cause and cause-specific outcomes in heart failure (HF) remains unexplored. Using a previously validated territory-wide clinical information registry, all eligible patients diagnosed with HF (N = 127124) from 2000 to 2020 were included. In this population-based cohort (mean age: 71.4 ± 12.2 years, 51.8% male), the association between triglyceride levels and risk of all-cause mortality and cardiovascular disease was a U-shapedḍ curve. High triglyceride levels (≥3.0 mmol/L) were associated with atherosclerotic cardiovascular disease admission or death; conversely, lower triglyceride levels (<1.2 mmol/L) were associated with higher risks of HF readmission or death. The risk of adjusted all-cause mortality reached a nadir between triglyceride levels of 1.2 mmol/L and 3.0 mmol/L. Results were externally validated in BIOSTAT-CHF. Our findings have important implications for defining the role of triglyceride levels in contributing to the diverse outcomes in patients with HF.
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