Evidence map›Paper›PMID 39915439›Full record

ArticleNature communications2025

A visual cortical-lateral posterior thalamic nucleus circuit regulates depressive-like behaviors in male mice.

Fangfang Wu, Chenxi Gu, Rui Xu, Junwei Ma, Lei Gao, Youjiao Zhang, Siyuan Bu, Qingbo Lu, Te Zhao, Yijun Han and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Repeated restraint stress enhances visual plasticity through locus coeruleus (LC)-V1 projection in adult mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fangfang WuDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China. fangfang.wu@njucm.edu.cn.ORCID http://orcid.org/0000-0003-4033-6644
Chenxi GuJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, China.
Rui XuDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Junwei MaDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Lei GaoDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Youjiao ZhangDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Siyuan BuDepartment of Neurology, Affiliated Zhongda Hospital and Jiangsu Provincial Medical Key Discipline, School of Medicine, Southeast University, Nanjing, China.
Qingbo LuDepartment of Neurology, Affiliated Zhongda Hospital and Jiangsu Provincial Medical Key Discipline, School of Medicine, Southeast University, Nanjing, China.
Te ZhaoShenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression, Department of Mental Health and Public Health, Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Yijun HanShenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression, Department of Mental Health and Public Health, Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Chen GuoDepartment of Neurology of Sir Run Run Shaw Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Yihui CuiDepartment of Neurology of Sir Run Run Shaw Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, China.ORCID http://orcid.org/0000-0002-7362-6237
Jianhua DingJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, China.
Gang HuDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China. ghu@njmu.edu.cn.
Zhijun ZhangDepartment of Neurology, Affiliated Zhongda Hospital and Jiangsu Provincial Medical Key Discipline, School of Medicine, Southeast University, Nanjing, China. janemengzhang@vip.163.com.ORCID http://orcid.org/0000-0001-5480-0888

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression, a prevalent psychiatric disorder of ambiguous etiology and high heterogeneity, has been recently linked to the primary visual cortex (V1). However, the precise circuits mediating the impact of V1 on depressive-like behaviors are poorly understood. Here, we demonstrate that the V1, specifically the lateral posterior nucleus of the thalamus (LP)-projecting V1 glutamatergic subpopulation (Glu

Indexed as

DepressionLateral Thalamic NucleiVisual CortexAnimalsBehavior, AnimalMaleMiceMice, Inbred C57BLNeuronsOptogeneticsRestraint, PhysicalStress, Psychological

Identifiers

PMID39915439
PMCPMC11802872

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.