Evidence map›Paper›PMID 39915363›Full record

ReviewAmerican journal of clinical dermatology2025

Infections in Patients with Atopic Dermatitis and the Influence of Treatment.

Maddalena Napolitano, Maria Esposito, Maria Concetta Fargnoli, Giampiero Girolomoni, Paolo Romita, Elena Nicoli, Paolo Matruglio, Caterina Foti

Abstract readReview
In one paragraph

Review in American journal of clinical dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Correlation betweenFrontiers in immunology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maddalena Napolitano *Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.ORCID http://orcid.org/0000-0003-3309-8190
Maria Esposito *Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio, Coppito 2, 67100, L'Aquila, Italy.ORCID http://orcid.org/0000-0002-4773-6993
Maria Concetta FargnoliSan Gallicano Dermatological Institute - IRCCS, Rome, Italy. mariaconcetta.fargnoli@ifo.it.ORCID http://orcid.org/0000-0002-7249-2556
Giampiero GirolomoniDepartment of Medicine, Section of Dermatology, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0001-8548-0493
Paolo RomitaDepartment of Precision Medicine and Regeneration and Ionian Area, Unit of Dermatology, University of Bari Aldo Moro, Bari, Italy.ORCID http://orcid.org/0000-0002-5559-9722
Elena NicoliSanofi, Milan, Italy.
Paolo MatruglioSanofi, Milan, Italy.
Caterina FotiDepartment of Precision Medicine and Regeneration and Ionian Area, Unit of Dermatology, University of Bari Aldo Moro, Bari, Italy.ORCID http://orcid.org/0000-0001-6196-9788

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atopic dermatitis (AD) is a T helper 2-mediated chronic inflammatory skin disease that affects children and adults. Patients with AD are prone to recurrent infections of the skin and other organs, which can severely worsen the disease course. This review summarises the current evidence on the aetiology, pathogenesis, treatment and prevention of infections in patients with AD. PubMed was searched for English-language research articles, systematic reviews, meta-analyses and guidelines published until February 2023 using the key term "atopic dermatitis" and terms relevant to infections. Patients with AD have an increased risk of bacterial, viral and fungal infections of the skin, mainly due to impaired barrier function, altered immune response and frequent scratching. The most common pathogens are Staphylococcus aureus and herpes simplex virus, which can cause impetigo, folliculitis, abscesses, eczema herpeticum and other complications. They also appear to increase susceptibility to systemic infections, including respiratory and urinary tract infections and sepsis. Certain systemic treatments for AD, such as mycophenolate mofetil and Janus kinase inhibitors, increase the risk of viral infections. Prevention and treatment of recurrent infections in patients with AD require a multifaceted approach that includes topical and systemic antimicrobials, skin care and effective control of AD symptoms (to break the itch-scratch cycle). Preventing and limiting the development of infections are important considerations in choosing an AD treatment.

Indexed as

Dermatitis, AtopicInfectionsHumans

Identifiers

PMID39915363
PMCPMC11850493

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.