Evidence map›Paper›PMID 39915357›Full record

ArticleMolecular neurobiology2025

OSBP Participates in Neural Damage Repair by Regulating Lysosome Transport Under Oxidative Stress.

Maoxing Fei, Shiqiao Luo, Chaochao Gao, Xiwen Huang, Lan Wang, Tianle Jin, Mingda Liu, Mengliang Zhou, Handong Wang

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Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Maoxing FeiNanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Shiqiao LuoDepartment of Neurosurgery, The Affiliated Jinling Hospital of Nanjing Medical University, Nanjing, China.
Chaochao GaoDepartment of Neurosurgery, The Affiliated Jinling Hospital of Nanjing Medical University, Nanjing, China.
Xiwen HuangDepartment of Neurosurgery, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China.
Lan WangDepartment of Neurosurgery, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China.
Tianle JinDepartment of Neurosurgery, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China.
Mingda LiuDepartment of Core Laboratory, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China.
Mengliang ZhouNanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. zhoumengliang@nju.edu.cn.
Handong WangNanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. njhdwang@hotmail.com.

Funding

National Natural Science Foundation of China 82271426
6 · The paper itself

Abstract

Oxidative stress is a major pathological factor in acute brain injury, such as traumatic brain injury (TBI). As highly branched cells, the transport of lysosomes plays a crucial role in neuronal homeostasis. However, the effects and mechanisms of oxidative damage on axonal lysosome transport remain unknown. In this study, we demonstrated that the downregulation of the membrane lipid orchestrator oxysterol-binding protein (OSBP) induced by oxidative stress alters the subcellular distribution of lysosomes in neurons through regulating lysosomal phosphatidylinositol-4-monophosphate (PI(4)P)/phosphatidylinositol-3-monophosphate (PI(3)P) contents, thus disrupting lysosomal transport. The results of the cell experiments confirmed the occurrence of an autophagic pressure burst, disordered anterograde lysosome transport, and an imbalance in the PI(4)P/PI(3)P ratio in neurons after H

Indexed as

LysosomesNeuronsOxidative StressAnimalsAutophagyBiological TransportHydrogen PeroxideMicePhosphatidylinositol PhosphatesHydrogen PeroxidePhosphatidylinositol PhosphatesAnterograde transportLysosomeOxidative stressOxysterol-binding proteinTraumatic brain injury

Identifiers

PMID39915357

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.