Evidence map›Paper›PMID 39915353›Full record

ReviewWorld journal of microbiology & biotechnology2025

Production of aromatic amino acids and their derivatives by Escherichia coli and Corynebacterium glutamicum.

Takashi Hirasawa, Yasuharu Satoh, Daisuke Koma

Abstract readReview
In one paragraph

Review in World journal of microbiology & biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Adaptive Laboratory Evolution inMicroorganisms · 2026
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Takashi HirasawaSchool of Life Science and Technology, Institute of Science Tokyo, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa, 226-8501, Japan. thirasawa@life.isct.ac.jp.ORCID http://orcid.org/0000-0002-5183-2953
Yasuharu SatohFaculty of Engineering, Hokkaido University, N13 & W8, Kita-ku, Sapporo, Hokkaido, 060-8628, Japan.ORCID http://orcid.org/0000-0001-6671-7758
Daisuke KomaOsaka Research Institute of Industrial Science and Technology, 1-6-50 Morinomiya, Joto-ku, Osaka, 536-8553, Japan.ORCID http://orcid.org/0000-0002-8255-5872

Funding

Japan Science and Technology Agency JPMJTR23U4Japan Society for the Promotion of Science JP22K04835
6 · The paper itself

Abstract

Demand for aromatic amino acids (AAAs), such as L-phenylalanine, L-tyrosine, and L-tryptophan, has been increasing as they are used in animal feed and as precursors in the synthesis of industrial and pharmaceutical compounds. These AAAs are biosynthesized through the shikimate pathway in microorganisms and plants, and the reactions in the AAA biosynthesis pathways are strictly regulated at the levels of both gene expression and enzyme activity. Various attempts have been made to produce AAAs and their derivatives using microbial cells and to optimize production. In this review, we summarize the metabolic pathways involved in the biosynthesis of AAAs and their regulation and review recent research on AAA production using industrial bacteria, such as Escherichia coli and Corynebacterium glutamicum. Studies on fermentative production of AAA derivatives, including L-3,4-dihydroxyphenylalanine, tyrosol, and 3-hydroxytyrosol, are also discussed.

Indexed as

Amino Acids, AromaticCorynebacterium glutamicumEscherichia coliBiosynthetic PathwaysFermentationGene Expression Regulation, BacterialIndustrial MicrobiologyMetabolic EngineeringMetabolic Networks and PathwaysPhenylethyl AlcoholShikimic AcidTyrosine4-hydroxyphenylethanolAmino Acids, AromaticPhenylethyl AlcoholShikimic AcidTyrosineAromatic amino acid derivativesAromatic amino acidsCorynebacterium glutamicumEscherichia coliFermentative production

Identifiers

PMID39915353
PMCPMC11802643

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.