ArticleSurgery today2025
Risk factors of poor long-term outcomes in elderly patients with esophageal squamous cell carcinoma after minimally invasive esophagectomy.
Article in Surgery today, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Clinical advantage of robot-assisted over conventional minimally invasive esophagectomy in patients with a narrow mediastinum.Surgical endoscopy · 2026Article
- Article
- The Geriatric Nutritional Risk Index and pulmonary function predict non-esophageal cancer-related mortality after esophagectomy.Esophagus : official journal of the Japan Esophageal Society · 2026Article
- Study on the survival prognosis of over 80 years old patients of esophageal cancer with other cancers-based on SEER data analysis.Scientific reports · 2025Article
- Surgical treatment strategy for elderly patients with esophageal cancer in the new era: a narrative review.Surgery today · 2025Review
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeElderly patients with esophageal squamous cell carcinoma (ESCC) have more comorbidities than young patients do. Elderly smokers have a high mortality rate owing to physical dysfunction. This study aimed to identify risk factors for long-term outcomes after minimally invasive esophagectomy (MIE) in elderly patients with ESCC.
methodsThis study included 110 elderly patients (aged ≥ 75 years) with ESCC who underwent MIE at Kobe University Hospital. Multivariate Cox proportional hazards regression analyses were performed to identify risk factors, including the geriatric nutritional risk index (GNRI), Charlson comorbidity index, and elderly smoker status, defined as smoking at the age of 70 years.
resultsMultivariate analysis identified that elderly smokers, cT or cN status (≥ cT2 or cN-positive), and GNRI (≤ 92) were independent prognostic factors for overall survival (p = 0.026, 0.019, and 0.038, respectively). For patients with ≥ cT2 or cN-positive ESCC, elderly smokers or patients with GNRI (≤ 92) have significantly worse survival (p = 0.038). Elderly smokers were at risk of death from other diseases five years postoperatively (p = 0.016).
conclusionsElderly smokers, cT2 or cN positivity, and low GNRI were risk factors for poor survival. Furthermore, for patients with ≥ cT2 or cN-positive ESCC, these risk factors were associated with poor survival.
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