ArticleNature cardiovascular research2025
IL-1β enhances susceptibility to atrial fibrillation in mice by acting through resident macrophages and promoting caspase-1 expression.
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Article in Nature cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
–field-weighted citation impact
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Who cites it
12 citing papers in PubMed.
- Acute interleukin-1β antagonism decreases systemic inflammation, increases GLP-1 release, and modulates insulin secretion in individuals with prediabetes.American journal of physiology. Endocrinology and metabolism · 2026Trial
- Tissue-Resident Macrophages: Linking Physiology and Inflammation in Infection.Clinical reviews in allergy & immunology · 2026Review
- P2X7-NEK7-NLRP3 Axis Drives Cardiac Inflammation and Fibrosis in Isoproterenol-Induced Cardiac Remodeling in Mice.Acta physiologica (Oxford, England) · 2026Article
- The Immune System as a Proarrhythmic Mediator: A Novel Paradigm for the Development of New Antiarrhythmic Therapy.The Canadian journal of cardiology · 2026Review
- Inflammation-Mediated Mechanisms of Arrhythmias After Acute Myocardial Infarction.Reviews in cardiovascular medicine · 2026Review
- The impact of inflammation, neuromodulation, and gut microbiota on developing cardiac fibrosis and hypertension.Cardiovascular research · 2026Review
- Article
- Protocol to generate immunocompetent human heart-macrophage assembloids for the study of immune-cardiac interactions.STAR protocols · 2026Article
- Autonomic nervous system modulation in arrhythmias: mechanisms and therapeutic advances.Frontiers in physiology · 2026Review
- Metabolic and Inflammatory Mechanisms Driving Atrial Fibrillation.Annual review of pharmacology and toxicology · 2026Review
- Cardiac resident macrophages: the emerging role in arrhythmogenesis.Frontiers in immunology · 2026Review
- Inflammatory and fibrotic signaling pathways mediated by cardiac macrophages in atrial fibrillation.Frontiers in cardiovascular medicine · 2025Review
Corrections and comments
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Authors and funding
56 authors.
Oscar Moreno-LoaizaInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Vinicius Cardoso SoaresLaboratory of Immunopharmacology, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-0552-5995
Manuela de Assumpção SouzaInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Narendra Vera-NuñezInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Ainhoa Rodriguez de Yurre GuiraoInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-5920-7028
Tatiana Pereira da SilvaInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-4016-3002
Ana Beatriz PozesInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Larissa PerticarrariInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Evelin MonteiroInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Maria Clara AlbinoInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Sophia Barros SilvaInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Suelen Silva Gomes DiasLaboratory of Immunopharmacology, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-3104-0983
Leonardo MacielInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Humberto Muzi-FilhoInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-9183-1699
Dahienne Ferreira de OliveiraInstitute of Medical Biochemistry Leopoldo de Meis, Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Bruno Cabral BragaInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Luan Pereira DinizInstitute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Mario Costa CruzCentro de Facilidades e Apoio à Pesquisa (CEFAP), Universidade de São Paulo (USP), São Paulo, Brazil.
Simone Reis BarbosaD'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
Archimedes Barbosa Castro-JuniorInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Luciana CondeInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Mauro Jorge Cabral-CastroInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Olga Ferreira de SouzaD'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
Martha Valéria Tavares PinheiroD'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
Nilson Araújo de Oliveira JuniorD'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
Leonardo Rezende de SiqueiraD'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
Rodrigo Periquito CosenzaD'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
Claudio Munhoz da FontouraD'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
Jose Carlos Pizzolante SeccoD'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.ORCID http://orcid.org/0009-0000-8094-3778
Juliana da Rocha FerreiraD'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
Andréa Silvestre de SousaD'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0001-8266-4801
Denilson AlbuquerqueRio de Janeiro State University, Rio de Janeiro, Brazil.
Ronir Raggio LuizInstitute for Studies in Public Health-IESC, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Pedro Nicolau-NetoMolecular Carcinogenesis Program, Research Coordination, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil.
Marco Antonio PrettiCell and Gene Therapy Program, Research Coordination, National Cancer Institute (INCA), Rio de Janeiro, Brazil.
Mariana BoroniLaboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0003-3495-9917
Martin Hernán BonaminoMolecular Carcinogenesis Program, Research Coordination, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil.
Tais Hanae Kasai-BrunswickInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Debora Bastos MelloNational Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-2096-2907
Triciana Gonçalves-SilvaNational Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Isalira Peroba RamosNational Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Fernando A BozzaD'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
João Paulo do Vale MadeiroDepartment of Computing Science, Federal University of Ceará, Fortaleza, Brazil.
Roberto Coury PedrosaClementino Fraga University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Marcela Sorelli Carneiro-RamosCenter for Natural and Human Sciences, Federal University of ABC, Santo André, Brazil.
Herculano da Silva MartinhoCenter for Natural and Human Sciences, Federal University of ABC, Santo André, Brazil.
Patrícia T BozzaLaboratory of Immunopharmacology, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0001-8349-9529
Fernanda Mesquita de SouzaCenter of Research in Inflammatory Diseases (CRID), Ribeirão Preto Medical School, Ribeirão Preto, Brazil.
Gabriel Victor Lucena da SilvaCenter for Natural and Human Sciences, Federal University of ABC, Santo André, Brazil.ORCID http://orcid.org/0000-0002-4435-659X
Thiago M CunhaCenter of Research in Inflammatory Diseases (CRID), Ribeirão Preto Medical School, Ribeirão Preto, Brazil.ORCID http://orcid.org/0000-0003-1084-0065
Ilija UzelacVirginia Commonwealth University, Richmond, VA, USA.
Flavio FentonSchool of Physics, Georgia Tech, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-4089-8850
Renata Moll-BernardesD'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0001-8587-7319
Claudia N PaivaInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Ariel L EscobarDepartment of Bioengineering, School of Engineering, University of California, Merced, CA, USA.
Emiliano MedeiInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. emedei70@biof.ufrj.br.ORCID http://orcid.org/0000-0002-0044-1311
Funding
Integrative High-Resolution Experimental and Multiscale Modeling of Arrhythmias to Optimize Low Energy Anti-fibrillation Pacing (LEAP)R01HL143450 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI Flavio H Fenton · 2018 to 2026
$3.2MNHLBI NIH HHS R01 HL143450
Abstract
Atrial fibrillation (AF) is more prevalent in patients with elevated interleukin (IL)-1β levels. Here we show that daily administration of IL-1β for 15 days sensitizes mice to AF, leading to fibrosis, accumulation of β-pleated sheet proteins in the left atrium, and systemic inflammation, resembling the pathophysiological changes observed in patients with AF. IL-1β administration creates a positive feedback loop, dependent on the IL-1 receptor (IL-1R) activity in cardiac resident macrophages. This results in increased caspase-1 maturation in the left atrium and elevated Il1b and Casp1 transcription in atrial macrophages. IL-1β treatment accelerated action potential and Ca
Indexed as
Atrial FibrillationCaspase 1Heart AtriaInterleukin-1betaMacrophagesAction PotentialsAnimalsDisease Models, AnimalDisease SusceptibilityFibrosisMaleMiceMice, Inbred C57BLMice, KnockoutMyocytes, CardiacReceptors, Interleukin-1Casp1 protein, mouseCaspase 1IL1B protein, mouseIL1R1 protein, mouseInterleukin-1betaReceptors, Interleukin-1Receptors, Interleukin-1 Type I
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