ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025
The effects of prognostic nutritional index, systemic immune inflammation index and HALP score on fistula formation, recurrence and mortality in laryngeal cancer patients.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic Value of the Haemoglobin-Albumin-Lymphocyte-Platelet Score in Head and Neck Cancer: A Systematic Review and Meta-Analysis.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026Pooled it
- Article
- The HALP score is a novel prognostic biomarker in multiple myeloma: A retrospective cohort study of 450 patients.Medicine · 2026Article
- Prognostic role of HALP score, CRP/albumin ratio and CALLY index in diabetic foot ulcer-related major amputations.Langenbeck's archives of surgery · 2025Article
- Prognostic significance of nutritional and inflammatory markers in locoregional advanced laryngeal cancer undergoing total laryngectomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- The joint role of systemic immune-inflammation index and geriatric nutritional risk index in cancer survivors and their impact on all-cause mortality.Frontiers in nutrition · 2025Article
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5 authors.
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Abstract
purposeThe aim of this study was to investigate the effects of prognostic nutritional index (PNI), systemic immune inflammation index (SII) and hemoglobin, albumin, lymphocyte, platelet (HALP) score on fistula formation, recurrence and mortality in patients with laryngeal cancer.
methodThe study included 77 patients who underwent total laryngectomy operation between 2018 and 2021. 66 (85.7%) patients underwent primary and 11 (14.3%) patients underwent salvage total laryngectomy. PNI, SII and HALP scores and cutt-off values of all patients were determined and the relationships between pharyngocutaneous fistula (PCF) formation, recurrence and mortality were statistically analysed. The patients with a score less than the cut-off value were divided into two groups as Group 1, and the patients with a score equal to or greater than the cut-off value were divided into two groups as Group 2.
resultsThe effect of PNI, SII and HALP on the development of FKF was not significant (P = 0.110, P = 0.135, P = 0.358). The effect of high SII and low HALP score on the development of recurrence was statistically significant (P = 0.001, P = 0.012). Low PNI increased the development of recurrence, but this increase was not statistically significant (P = 0.075). Overall survival rate was 68.8%. The effect of low PNI and HALP on survival was statistically significant (P = 0.011, P = 0.021). The effect of high SII on survival was not significant (P = 0.533).
conclusionLow PNI index and HALP score and high SII index are cost-effective simple prognostic biomarkers that are significant in the development of FCF, as well as in the evaluation of recurrence and overall survival in the long-term follow-up of these patients.
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