Evidence map›Paper›PMID 39915224›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2025

Fast ripple band high-frequency activity associated with thalamic sleep spindles in pediatric epilepsy.

Atsuro Daida, Yuanyi Ding, Yipeng Zhang, Shingo Oana, Saarang Panchavati, Benjamin D Edmonds, Samuel S Ahn, Noriko Salamon, Raman Sankar, Aria Fallah and 5 more

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Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Atsuro DaidaDivision of Pediatric Neurology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine Los Angeles CA USA. Electronic address: adaida@mednet.ucla.edu.
Yuanyi DingDepartment of Electrical and Computer Engineering, University of California Los Angeles CA USA.
Yipeng ZhangDepartment of Electrical and Computer Engineering, University of California Los Angeles CA USA.
Shingo OanaDivision of Pediatric Neurology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine Los Angeles CA USA.
Saarang PanchavatiDepartment of Radiological Sciences, University of California Los Angeles CA USA; Department of Bioengineering, University of California Los Angeles CA USA.
Benjamin D EdmondsDivision of Pediatric Neurology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine Los Angeles CA USA.
Samuel S AhnDivision of Pediatric Neurology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine Los Angeles CA USA.
Noriko SalamonDepartment of Radiological Sciences, University of California Los Angeles CA USA.
Raman SankarDivision of Pediatric Neurology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine Los Angeles CA USA; The UCLA Children's Discovery and Innovation Institute Los Angeles CA USA.
Aria FallahDepartment of Neurosurgery, UCLA Medical Center, David Geffen School of Medicine Los Angeles CA USA.
Richard J StabaDepartment of Neurology, UCLA Medical Center, David Geffen School of Medicine Los Angeles CA USA.
Jerome EngelDepartment of Neurology, UCLA Medical Center, David Geffen School of Medicine Los Angeles CA USA; Department of Neurobiology, University of California Los Angeles CA USA; Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles CA USA; The Brain Research Institute, University of California Los Angeles CA USA.
William SpeierDepartment of Radiological Sciences, University of California Los Angeles CA USA; Department of Bioengineering, University of California Los Angeles CA USA.
Vwani RoychowdhuryDepartment of Electrical and Computer Engineering, University of California Los Angeles CA USA.
Hiroki NariaiDivision of Pediatric Neurology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine Los Angeles CA USA; The UCLA Children's Discovery and Innovation Institute Los Angeles CA USA. Electronic address: hnariai@mednet.ucla.edu.

Funding

Refining neurophysiological biomarkers of epilepsy using deep learning to guide pediatric epilepsy surgeryK23NS128318 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Hiroki Nariai · 2023 to 2026
$968k
NINDS NIH HHS K23 NS128318
6 · The paper itself

Abstract

objectiveTo investigate high-frequency activities (HFA) associated with thalamic sleep spindles.

methodsWe studied a cohort of ten pediatric patients with medication resistant epilepsy who were identified as potential candidates for thalamic neuromodulation. These patients had thalamic sampling as well as presumed epileptogenic zones, using stereotactic EEG (SEEG) with a sampling frequency of 2,000 Hz. We quantified the summated high-frequency activity (HFA) in the fast ripple band associated with sleep spindles using 20-minute scalp EEG and SEEG recordings during non-REM sleep and analyzed its correlation with spindle characteristics.

resultsHFA, with a median peak frequency of 330 Hz, was distinctively observed in the thalamus and temporally correlated with thalamic sleep spindles. Such HFA demonstrated significant coupling with the sleep spindle range of 11-16 Hz. The duration of HFA positively correlated with higher density and longer duration of accompanying thalamic spindles. Thalamic HFA's duration negatively correlated with the presence of cortical interictal epileptiform discharges. Thalamic spindles generated in channels with HFA often coincided with sleep spindles in various brain regions.

conclusionFast ripple band HFA associated with sleep spindles was observed exclusively in the thalamus. SIGNIFICANCE: Thalamic HFA associated with thalamic spindles may represent a thalamus-specific physiological phenomenon.

Indexed as

Drug Resistant EpilepsyEpilepsySleepSleep StagesThalamusAdolescentChildChild, PreschoolElectroencephalographyFemaleHumansMaleEpilepsyFast rippleHigh frequency oscillationsSpindleStereotactic EEGThalamus

Identifiers

PMID39915224
PMCPMC13152191

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.