Evidence map›Paper›PMID 39915034›Full record

ArticleTuberculosis and respiratory diseases2025

International Severe Asthma Registry (ISAR): 2017-2024 Status and Progress Update.

Désirée Larenas-Linnemann, Chin Kook Rhee, Alan Altraja, John Busby, Trung N Tran, Eileen Wang, Todor A Popov, Patrick D Mitchell, Paul E Pfeffer, Roy Alton Pleasants and 45 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tuberculosis and respiratory diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

55 authors.

Désirée Larenas-LinnemannCenter of Excellence in Asthma and Allergy, Médica Sur Hospital, Mexico City, Mexico.
Chin Kook RheeDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Alan AltrajaDepartment of Pulmonology, Lung Clinic, Tartu University Hospital, University of Tartu, Tartu, Estonia.
John BusbyCentre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Trung N TranBioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, USA.
Eileen WangDivision of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health, Denver, CO, USA.
Todor A PopovUniversity Hospital St. Ivan Rilski, Sofia, Bulgaria.
Patrick D MitchellSchool of Medicine, Trinity College Dublin, Dublin, Ireland.
Paul E PfefferDepartment of Respiratory Medicine, Barts Health NHS (National Health Services) Trust, London, UK.
Roy Alton PleasantsMarsico Lung Institute, University of North Carolina, Chapel Hill, NC, USA.
Rohit KatialDivision of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health, Denver, CO, USA.
Mariko Siyue KohDepartment of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.
Arnaud BourdinPhyMedExp, University of Montpellier, CNRS (National Center for Scientific Research), INSERM (The National Institute of Health and Medical Research), CHU (Centre Hospitalier Universitaire), Montpellier, France.
Florence SchleichDepartment of Pneumology, University Hospital of Liège, GIGA I3 Research Group, Exercise Physiology Lab, Department of Physical Activity and Rehabilitation Sciences, University of Liège, Liège, Belgium.
Jorge MásperoClinical Research for Allergy and Respiratory Medicine, CIDEA Foundation, Buenos Aires, Argentina.
Mark HewAllergy, Asthma & Clinical Immunology Service, Alfred Health, Melbourne, VIC, Australia.
Matthew J PetersDepartment of Thoracic Medicine, Concord Hospital, Sydney, NSW, Australia.
David J JacksonGuy's Severe Asthma Centre, School of Immunology & Microbial Sciences, King's College London, London, UK.
George C ChristoffFaculty of Public Health, Medical University, Sofia, Bulgaria.
Luis Perez-de-LlanoPneumology Service, Lucus Augusti University Hospital, EOXI Lugo, Monforte, Cervo, Spain.
Ivan Cherrez-OjedaHoly Spirit University, Samborondon, Ecuador.
João A FonsecaCINTESIS@RISE (Center for Health Technology and Services Research at Health Research Network), MEDCIDS (Departamento Medicina da Comunidade, Informação e Decisão em Saúde/Department of Community Medicine, Information and Health Decisions), Faculty of Medicine of the University of Porto, Porto, Portugal.
Richard W CostelloClinical Research Centre, Smurfit Building Beaumont Hospital, Department of Respiratory Medicine, RCSI (Royal College of Surgeons Ireland), Dublin, Ireland.
Carlos A Torres-DuqueCINEUMO (Centro Internacional de Investigación en Neumología), Respiratory Research Center, Fundación Neumológica Colombiana, Bogotá, Colombia.
Piotr KunaDivision of Internal Medicine Asthma and Allergy, Medical University of Lodz, Lodz, Poland.
Andrew N Menzies-GowBioPharmaceuticals Medical, AstraZeneca, Cambridge, UK.
Neda StjepanovicBioPharmaceuticals Medical, AstraZeneca, Gothenburg, Sweden.
Peter G GibsonAustralian Severe Asthma Network, Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, NSW, Australia.
Paulo Márcio PitrezPulmonology Division, Hospital Santa Casa de Porto Alegre, Porto Alegre, Brazil.
Celine BergeronDepartment of Medicine, Centre for Lung Health, Vancouver General Hospital, Vancouver, BC, Canada.
Celeste M PorsbjergDepartment of Respiratory Medicine and Infectious Diseases, Research Unit, Bispebjerg Hospital, Copenhagen, Denmark.
Camille TailléDepartment of Respiratory Diseases, Bichat Hospital, AP-HP (L'Assistance Publique - Hôpitaux de Paris), Nord-Université Paris Cité, Paris, France.
Christian TaubeDepartment of Pulmonary Medicine, University Medical Center Essen-Ruhrlandklinik, Essen, Germany.
Nikolaos G PapadopoulosDivision of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, UK.
Andriana I Papaioannou2nd Respiratory Medicine Department, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, Athens, Greece.
Sundeep SalviPulmocare Research and Education Foundation, Pune, India.
Giorgio Walter CanonicaPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Enrico HefflerPersonalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Takashi IwanagaSleep Medicine Centre, Kindai University Hospital, Osakasayama, Japan.
Mona S Al-AhmadMicrobiology Department, College of Medicine, Kuwait University, Kuwait City, Kuwait.
Sverre LehmannSection of Thoracic Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.
Riyad Al-LehebiDepartment of Pulmonology, King Fahad Medical City, Riyadh, Saudi Arabia.
Borja G CosioSon Espases University Hospital-IdISBa (Institut d'Investigació Sanitària Illes Balears)-Ciberes, Mallorca, Spain.
Diahn-Warng PerngSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Bassam MahboubRashid Hospital, Dubai Health (DH), Dubai, United Arab Emirates.
Liam G HeaneyWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.
Pujan H PatelRespiratory Medicine, Royal Brompton Hospital, London, UK.
Njira LugogoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan, Ann Arbor, MI, USA.
Michael E WechslerDepartment of Medicine, National Jewish Health Cohen Family Asthma Institute, National Jewish Health, Denver, CO, USA.
Lakmini BulathsinhalaObservational and Pragmatic Research Institute, Singapore, Singapore.
Victoria CarterObservational and Pragmatic Research Institute, Singapore, Singapore.
Kirsty FlettonObservational and Pragmatic Research Institute, Singapore, Singapore.
David L NeilObservational and Pragmatic Research Institute, Singapore, Singapore.
Ghislaine SceloObservational and Pragmatic Research Institute, Singapore, Singapore.
David B PriceObservational and Pragmatic Research Institute, Singapore, Singapore.

Funding

International Severe Asthma RegistryObservational and Pragmatic Research InstituteOptimum Patient Care GlobalPte. Ltd.
6 · The paper itself

Abstract

The International Severe Asthma Registry (ISAR) was established in 2017 to advance the understanding of severe asthma and its management, thereby improving patient care worldwide. As the first global registry for adults with severe asthma, ISAR enabled individual registries to standardize and pool their data, creating a comprehensive, harmonized dataset with sufficient statistical power to address key research questions and knowledge gaps. Today, ISAR is the largest repository of real-world data on severe asthma, curating data on nearly 35,000 patients from 28 countries worldwide, and has become a leading contributor to severe asthma research. Research using ISAR data has provided valuable insights on the characteristics of severe asthma, its burdens and risk factors, real-world treatment effectiveness, and barriers to specialist care, which are collectively informing improved asthma management. Besides changing clinical thinking via research, ISAR aims to advance real-world practice through initiatives that improve registry data quality and severe asthma care. In 2024, ISAR refined essential research variables to enhance data quality and launched a web-based data acquisition and reporting system (QISAR), which integrates data collection with clinical consultations and enables longitudinal data tracking at patient, center, and population levels. Quality improvement priorities include collecting standardized data during consultations and tracking and optimizing patient journeys via QISAR and integrating primary/secondary care pathways to expedite specialist severe asthma management and facilitate clinical trial recruitment. ISAR envisions a future in which timely specialist referral and initiation of biologic therapy can obviate long-term systemic corticosteroid use and enable more patients to achieve remission.

Indexed as

Core VariablesDelphi ConsensusInternational Severe Asthma Registry (ISAR)Optimum Patient Care GlobalQuality ImprovementReal-World Data

Identifiers

PMID39915034
PMCPMC12010726

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.