Evidence map›Paper›PMID 39915023›Full record

ArticleBMJ open2025

The REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study.

Wendy Ziai, Daniel Woo, Lauren Sansing, Daniel Hanley, Noeleen Ostapkovich, Kevin Triene, Lee A Gilkerson, Richard Thompson, Nathan Walborn, Karen Lane and 5 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05611918 (The Repeated Assessment of Survivors in ICH), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05611918 active not recruitingnot on this map

The Repeated Assessment of Survivors in ICH (REASSESS ICH)

TypeobservationalSponsorJohns Hopkins UniversityRan2023 to 2027Enrolled350ConditionsIntra Cerebral Hemorrhage, ICH - Intracerebral Hemorrhage, ICH, Hemorrhage
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Wendy ZiaiDivision of Neurocritical Care, Department of Neurology and Neurosurgery, Johns Hopkins University, Baltimore, Maryland, USA weziai@jhmi.edu.ORCID http://orcid.org/0000-0003-4548-7353
Daniel WooDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Lauren SansingDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
Daniel HanleyDivision of Brain Injury Outcomes, Department of Neurology and Neurosurgery, Johns Hopkins University, Baltimore, Maryland, USA.
Noeleen OstapkovichDivision of Brain Injury Outcomes, Department of Neurology and Neurosurgery, Johns Hopkins University, Baltimore, Maryland, USA.
Kevin TrieneDivision of Brain Injury Outcomes, Department of Neurology and Neurosurgery, Johns Hopkins University, Baltimore, Maryland, USA.
Lee A GilkersonDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Richard ThompsonDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Nathan WalbornDivision of Brain Injury Outcomes, Department of Neurology and Neurosurgery, Johns Hopkins University, Baltimore, Maryland, USA.
Karen LaneDivision of Brain Injury Outcomes, Department of Neurology and Neurosurgery, Johns Hopkins University, Baltimore, Maryland, USA.
Nichol McBeeDivision of Brain Injury Outcomes, Department of Neurology and Neurosurgery, Johns Hopkins University, Baltimore, Maryland, USA.
Carl D LangefeldDepartment of Biostatistics and Data Science (CDL), Biochemistry (TDH) and the Center for Precision Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Timothy David HowardDepartment of Biostatistics and Data Science (CDL), Biochemistry (TDH) and the Center for Precision Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Achala VagalDepartment of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Matthew L FlahertyDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
REpeated ASseSsmEnt of SurvivorS in ICH (REASSESS ICH)R01NS120557 · NINDS · JOHNS HOPKINS UNIVERSITY · PI FLAHERTY, MATTHEW, ZIAI, WENDY C · 2022 to 2025
$7.5M
NCATS NIH HHS UL1 TR001863NINDS NIH HHS R01 NS120557
6 · The paper itself

Abstract

backgroundThe REpeated ASSEssment of SurvivorS (REASSESS) study will conduct long-term cognitive, functional and neuropsychiatric performance assessments to determine whether evacuation of spontaneous intracerebral haemorrhage (ICH) reduces the risk of later cognitive decline in the ageing brain. METHODS AND ANALYSIS: This study will compare rates of cognitive decline under two treatment strategies for ICH. The first strategy is the use of minimally invasive surgery (MIS) with similar techniques as performed in (1) the Minimally Invasive Surgery plus rt-PA in the Treatment of Intracerebral haemorrhage Evacuation phase III (MISTIE III) trial, (2) the Early MiNimally-invasive Removal of IntraCerebral Haemorrhage (ENRICH) trial and (3) a single-centre cohort of consecutively treated patients with MIS. The second strategy is the current non-surgical standard of care using data from controls in MISTIE III and ENRICH and comparative data from The Ethnic/Racial Variations of ICH (ERICH) studyextended into the ERICH-Longitudinal study, which followed over 900 of ERICH cases with serial cognitive examinations. If successful, the REASSESS study could demonstrate that reduction of ICH volume is a critical target to reduce the risk of progressive cognitive decline, establish targets for residual haematoma volume reduction and determine if greater residual haematoma volume leads to a long-term inflammatory state. ETHICS AND DISSEMINATION: Approval of this study was obtained from the Johns Hopkins University Institutional Review Board (IRB00311985). The findings of the study will be published in academic peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT05611918; ClinicalTrials.gov; registered on 23 May 2023.

Indexed as

Cerebral HemorrhageCognitive DysfunctionSurvivorsFemaleHumansMaleMinimally Invasive Surgical ProceduresMulticenter Studies as TopicNeuropsychological TestsObservational Studies as TopicProspective StudiesDementiaIntracerebral HemorrhageNEUROSURGERYObservational StudyStroke

Identifiers

PMID39915023
PMCPMC11800296

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.