Observational studyOpen heart2025
Atrial fibrillation outcomes in patients from Asia and non-Asia countries: insights from GARFIELD-AF.
Observational study in Open heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01090362 (Prospective, Multi Centre, International Registry of Male and Female Patients Newly Diagnosed With Atrial Fibrillation.), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective, Multi Centre, International Registry of Male and Female Patients Newly Diagnosed With Atrial Fibrillation.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical outcomes of off-label DOAC underdosing in Japanese patients with atrial fibrillation: a systematic review and meta-analysis.Journal of thrombosis and thrombolysis · 2025Pooled it
- BMI differences on anticoagulation with bivalirudin vs. heparin during primary PCI: a BRIGHT-4 subanalysis.BMC medicine · 2025Trial
- Systolic Blood Pressure Variability and Outcomes in Atrial Fibrillation: A Nationwide Population Study in Korea.Journal of Korean medical science · 2026Article
- Observational
- Expanded Application of the DOAC Score for Predicting Bleeding Events in All Anticoagulated Patients With Atrial Fibrillation: An Integrated Analysis of 2 Prospective Japanese Registries-RAFFINE and SAKURA-AF.Circulation reports · 2026Article
- Impact of Anaemia on Management and Outcomes in Patients With Atrial Fibrillation: Insights From European and Asian Cohorts.European journal of clinical investigation · 2026Article
- Atrial Fibrillation, Brain Structure and Cognitive Function: A Mediation Analysis.Korean circulation journal · 2026Article
- Real-world outcomes of oral anticoagulation in patients with atrial fibrillation at high risk of both bleeding and stroke: observational evidence from three international registries from middle East, Europe and Asia-Pacific.Journal of thrombosis and thrombolysis · 2026Observational
- Left Atrial Appendage Closure in Patients with Atrial Fibrillation and Intermediate-to-Borderline High Cardiovascular Risk: A Retrospective Propensity Match Cohort Study.Journal of cardiovascular development and disease · 2026Article
- The characteristics and clinical outcomes of atrial fibrillation patient in middle income country of Indonesia.Frontiers in cardiovascular medicine · 2026Article
- Clinical complexity in patients with atrial fibrillation: exploring differential risk profiles from European and Asian cohorts.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Regional Heterogeneity in the Risk of Thrombosis and Bleeding in Patients With Peripheral Artery Disease.JACC. Asia · 2025Article
- Stroke and bleeding risks in Asian and non-Asian patients with atrial fibrillation: further insights into the 'East Asian Paradox'.Open heart · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferences in the clinical outcomes and level of risk among Asian versus non-Asian patients with atrial fibrillation (AF) have been sparsely investigated.
objectiveTo provide a contemporary prospective comparison of outcomes for newly diagnosed patients with AF, between Asian and non-Asian regions.
methodsSix Asian countries (China, Japan, India, Singapore, South Korea and Thailand) and 29 countries outside Asia participated in the Global Anticoagulant Registry in the FIELD-AF (GARFIELD-AF) study. Newly diagnosed patients with AF, enrolled between 2010 and 2016, were followed up for≥2 years. The outcome studies were all-cause, cardiovascular and non-cardiovascular mortality, non-haemorrhagic stroke/systemic embolism (SE), major bleeding. The association of geographical region with clinical outcomes (event rates per 100 person-years) were estimated using multivariable Cox models.
results13 841/52 057 (26.6%) GARFIELD-AF participants were enrolled in Asia. Average age and prevalence of cardiovascular comorbidities were lower than in non-Asian countries and patients at high risk of stroke (ie, CHA
conclusionsPatients in Asian countries had a lower risk of all-cause mortality and major bleeding compared to the rest of the world. NOAC had evident benefits for reducing mortality and stroke across populations. Further studies on sociocultural impacts on OAC outcomes are needed. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov NCT01090362.
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