Evidence map›Paper›PMID 39914634›Full record

ArticleGastrointestinal endoscopy2025

Thirty-day hospital admission following high-risk outpatient ERCP: incidence and analysis of risk factors based on a secondary analysis of the Stent Versus Indomethacin trial dataset.

Patrick Yachimski, Jingwen Zhang, Gregory A Coté, Steven A Edmundowicz, Sachin Wani, Raj Shah, Ji Young Bang, Shyam Varadarajulu, Vikesh K Singh, Mouen Khashab and 30 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastrointestinal endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Patrick YachimskiDivision of Gastroenterology, Hepatology & Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jingwen ZhangDivision of Gastroenterology & Hepatology, Medical University of South Carolina, Charleston, South Carolina, USA.
Gregory A CotéDivision of Gastroenterology & Hepatology, Oregon Health & Science University, Portland, Oregon, USA.
Steven A EdmundowiczDivision of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Sachin WaniDivision of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Raj ShahDivision of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Ji Young BangOrlando Health Digestive Health Institute, Orlando Health, Orlando, Florida, USA.
Shyam VaradarajuluOrlando Health Digestive Health Institute, Orlando Health, Orlando, Florida, USA.
Vikesh K SinghDivision of Gastroenterology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Mouen KhashabDivision of Gastroenterology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Richard S KwonDivision of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan, USA.
James M ScheimanDivision of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan, USA.
Field F WillinghamDivision of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
Steven A KeilinDivision of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
Georgios I PapachristouDivision of Gastroenterology, Hepatology & Nutrition, Department of Medicine, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Amitabh ChakDivision of Gastroenterology, University Hospitals Case Medical Center, Cleveland, Ohio, USA.
Adam SlivkaDivision of Gastroenterology, Hepatology & Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Daniel MulladyDivision of Gastroenterology, Washington University School of Medicine, St Louis, Missouri, USA.
Vladimir KushnirDivision of Gastroenterology, Washington University School of Medicine, St Louis, Missouri, USA.
James BuxbaumDivision of Gastroenterology, Department of Medicine, University of Southern California, Los Angeles, California, USA.
Rajesh KeswaniDivision of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Timothy B GardnerSection of Gastroenterology and Hepatology, Department of Medicine, Dartmouth-Hitchcock Health, Lebanon, New Hampshire, USA.
Nauzer ForbesDivision of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.
Amit RastogiDivision of Gastroenterology and Hepatology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Andrew RossDivision of Gastroenterology, Virginia Mason Medical Center, Seattle, Washington, USA.
Joanna LawDivision of Gastroenterology, Virginia Mason Medical Center, Seattle, Washington, USA.
Yen-I ChenDivision of Gastroenterology, McGill University, Montreal, Quebec, Canada.
Alan BarkunDivision of Gastroenterology, McGill University, Montreal, Quebec, Canada.
Zachary L SmithDivision of Gastroenterology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Jose SerranoNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Bret PetersenDepartment of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA.
Andrew Y WangDivision of Gastroenterology and Hepatology, University of Virginia, Charlottesville, Virginia, USA.
John R SaltzmanDivision of Gastroenterology, Hepatology & Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Rebecca L SpitzerDivision of Gastroenterology & Hepatology, Medical University of South Carolina, Charleston, South Carolina, USA.
Collins OrdiahDivision of Gastroenterology & Hepatology, Medical University of South Carolina, Charleston, South Carolina, USA.
Cathie SpinoDepartment of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Lydia D FosterData Coordination Unit, Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Valerie Durkalski-MauldinData Coordination Unit, Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
B Joseph ElmunzerDivision of Gastroenterology & Hepatology, Medical University of South Carolina, Charleston, South Carolina, USA.
SVI Study Group

Funding

Stent vs. Indomethacin for Preventing Post-ERCP Pancreatitis: The SVI TrialU01DK104833 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ELMUNZER, BADIH JOSEPH · 2015 to 2020
$11.5M
NIDDK NIH HHS U01 DK104833
6 · The paper itself

Abstract

BACKGROUND AND

aimsERCP carries potential for serious adverse events, and there is risk for unplanned health encounters after the procedure. The primary objective of this study was to identify the rate of 30-day hospital admission after outpatient ERCP in patients at elevated risk for post-ERCP pancreatitis based on patient- and procedure-related risk factors. We also explored whether pancreatitis rates and lengths of hospital stay differ with delayed hospitalization (versus admission immediately after ERCP) and identified factors associated with 30-day hospital admission.

methodsHigh-risk patients in the Stent Versus Indomethacin trial who underwent outpatient ERCP were identified. The primary outcome was hospital admission within 30 days after outpatient ERCP. Patient and procedural factors associated with 30-day hospital admission were explored by means of univariable analysis followed by multivariable analysis, controlling for potential known confounders.

resultsAmong 768 patients at high risk for post-ERCP pancreatitis who underwent outpatient ERCP and were discharged home, 21.9% required hospitalization within 30 days. Compared with patients who underwent outpatient ERCP but were admitted immediately to the hospital after the procedure, patients who were discharged after ERCP and admitted later had a higher incidence of post-ERCP pancreatitis (40.5% vs 30.9%; P = .04), moderate to severe post-ERCP pancreatitis (24.4% vs 13.8%; P < .01), and longer length of hospital stay (6.2 d vs 3.7 d; P < .001). Factors associated with 30-day hospitalization included patient age (odds ratio [OR], 0.98; 95% CI, 0.97-0.99), biliary stent placement (OR, 1.62; 95% CI, 1.05-2.48), and attempt at pancreatic duct cannulation (OR, 1.64; 95% CI, 1.02-2.64).

conclusionsHigh-risk patients who undergo outpatient ERCP and are discharged home are at considerable risk for hospital admission within 30 days and have an increased rate of pancreatitis and longer length of hospital stay compared with outpatients admitted to the hospital immediately after ERCP, and some factors may predict this outcome. These findings should influence decision making and informed consent when electing to proceed with high-risk ERCP, recognizing that patients with sphincter of Oddi dysfunction were over-represented in this cohort, which may limit generalizability to a typical ERCP practice.

Indexed as

Cholangiopancreatography, Endoscopic RetrogradeHospitalizationPancreatitisStentsAgedAmbulatory Surgical ProceduresAnti-Inflammatory Agents, Non-SteroidalFemaleHumansIncidenceIndomethacinLength of StayMaleMiddle AgedRisk FactorsTime FactorsAnti-Inflammatory Agents, Non-SteroidalIndomethacin

Identifiers

PMID39914634
PMCPMC13518049

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.