Evidence map›Paper›PMID 39913962›Full record

ArticleNuclear medicine and biology

First-in-human healthy volunteer dosimetry studies of the excitatory amino acid transporter 2 (EAAT2) PET imaging tracer methyl N

Chih-Kai Chao, Joseph Blecha, Ilona Polvoy, Ryan Michael Nillo, Youngho Seo, David M Wilson, John R Forsayeth, Henry F VanBrocklin, John M Gerdes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nuclear medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trajectories of late-life depression: insights from molecular imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chih-Kai ChaoRio Pharmaceuticals, Inc., 18 Elsie St., San Francisco, CA 94110, USA. Electronic address: chihkai.chao@gmail.com.
Joseph BlechaDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St., Suite 350, San Francisco, CA 94107, USA. Electronic address: joseph.blecha@ucsf.edu.
Ilona PolvoyDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St., Suite 350, San Francisco, CA 94107, USA.
Ryan Michael NilloDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St., Suite 350, San Francisco, CA 94107, USA. Electronic address: ryanmichael.nillo@uscf.edu.
Youngho SeoDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St., Suite 350, San Francisco, CA 94107, USA. Electronic address: youngho.seo@ucsf.edu.
David M WilsonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St., Suite 350, San Francisco, CA 94107, USA. Electronic address: david.m.wilson@ucsf.edu.
John R ForsayethRio Pharmaceuticals, Inc., 18 Elsie St., San Francisco, CA 94110, USA. Electronic address: john.forsayeth@riopharmaceuticals.com.
Henry F VanBrocklinDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St., Suite 350, San Francisco, CA 94107, USA. Electronic address: henry.vanbrocklin@ucsf.edu.
John M GerdesRio Pharmaceuticals, Inc., 18 Elsie St., San Francisco, CA 94110, USA. Electronic address: jgerdesum@gmail.com.

Funding

First-in-Human evaluation of an astrocytic glutamate transporter (EAAT2) PET tracer in healthy and Alzheimer's diseased brainR01AG072743 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERDES, JOHN M, VANBROCKLIN, HENRY F. · 2022 to 2025
$3.2M
NIA NIH HHS R01 AG072743
6 · The paper itself

Abstract

OBJECTIVE AND

backgroundThe objective of this first-in-human study was to investigate the radiosynthesis, and the preliminary safety, biodistribution, and organ radiation dosimetry of the positron emission tomography (PET) imaging tracer methyl N PROCEDURES AND

methodsA multi-step high molar activity tracer radiosynthesis was devised to produce doses. Eight healthy human participants (four male and four female), aged 56-75, received a bolus intravenous injection of [ MAIN

findingsTracer was routinely produced in good radiochemical yields and as suitable high molar activity doses for injection. The [ PRINCIPAL

conclusionsInjection of [

Indexed as

Glutamate Plasma Membrane Transport ProteinsHealthy VolunteersPositron-Emission TomographyAgedFemaleHumansMaleMiddle AgedOrganic Cation Transporter 2RadiochemistryRadiometryTissue DistributionGlutamate Plasma Membrane Transport ProteinsOrganic Cation Transporter 2SLC22A2 protein, humanDosimetryEAAT2Fluorine-18HumanPETTracer

Identifiers

PMID39913962
PMCPMC13170702

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.