ArticleThe Journal of pharmacology and experimental therapeutics2025
Cocaine reinstates extinguished food responding in male cynomolgus monkeys with a history of self-administering cocaine under a concurrent drug versus food choice paradigm.
Article in The Journal of pharmacology and experimental therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- An evaluation of N-acetylcysteine in a sequential oxycodone and cocaine rat self-administration model.Experimental and clinical psychopharmacology · 2026Article
- Sex, social rank, and nicotine co-administration shape cocaine- and cocaethylene-induced reinstatement in monkeys.Frontiers in behavioral neuroscience · 2026Article
- More than just a prime: Cocaine gives monkeys the munchies.The Journal of pharmacology and experimental therapeutics · 2025Article
- Rate-dependent drug effects: History and contemporary implications.The Journal of pharmacology and experimental therapeutics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The rate-dependency principle postulates that "stimulants" tend to increase low baseline rates of response and decrease high baseline responses. One exception to this principle is that stimulants do not typically increase responses that has been extinguished. However, drug self-administration studies showed that stimulant pretreatments reinstated extinguished drug-maintained responses. The goal of this study was to determine the effects of noncontingent cocaine on extinguished food-maintained responding in 3 male cynomolgus monkeys with extensive cocaine self-administration experience. Monkeys had a >4-year history of self-administering cocaine under a concurrent cocaine versus food schedule of reinforcement. For this study, only the discriminative stimulus (S
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Registered trials
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