Evidence map›Paper›PMID 39913920›Full record

SynthesisObstetrics and gynecology2025

Risk of Placenta Accreta Spectrum Disorder After Prior Non-Cesarean Delivery Uterine Surgery: A Systematic Review and Meta-analysis.

Ru Yang, Lizi Zhang, Lu Sun, Jianli Wu, Shilei Bi, Miao Hu, Shijun Luo, Fang He, Jingsi Chen, Lin Yu and 3 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Obstetrics and gynecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Placenta Praevia and Placenta Accreta Spectrum: Diagnosis and Management: Green-Top Guideline No. 27a.BJOG : an international journal of obstetrics and gynaecology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. PFO in pregnancy: amniotic fluid embolism complicated by paradoxical embolism.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ru YangDepartment of Obstetrics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, and the Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, the Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, and the Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Lizi Zhang
Lu Sun
Jianli Wu
Shilei Bi
Miao Hu
Shijun Luo
Fang He
Jingsi Chen
Lin Yu
Qiying Zhu
Dunjin Chen
Lili Du

Funding

General Program of Guangdong Province Natural Science Foundation 2023A1515110989Natural Key R&D Program of China 2022YFC2704501Natural Key R&D Program of China 2022YFC2704503
6 · The paper itself

Abstract

objectiveTo evaluate the association between previous non-cesarean uterine surgery and placenta accreta spectrum (PAS) in subsequent pregnancies. DATA SOURCES: PubMed, EMBASE, the Cochrane Library, ClinicalTrials.gov , CNKI (China National Knowledge Infrastructure), and Wan-fang Database were searched from inception to April 2024, supplemented by manual searches. METHODS OF STUDY SELECTION: Studies included prospective, retrospective cohort, case-control, and cross-sectional studies involving pregnant women diagnosed with PAS and reporting at least one risk factor associated with previous uterine surgery. TABULATION, INTEGRATION, AND

resultsTwo authors independently screened potentially eligible studies and extracted data. The quality of the studies was assessed with the Newcastle-Ottawa Scale. The pooled odds ratios (ORs), adjusted ORs, and their 95% CIs were estimated with fixed- or random-effects models if the heterogeneity ( I2 ) was high. Sensitivity analyses were conducted to account for potential study bias. The main measures were myomectomy, uterine artery embolization, dilatation and curettage, hysteroscopic adhesiolysis, abortion, endometrial ablation, and operative hysteroscopy. A total of 38 studies involving 7,353,177 participants were included in the systematic review, with an overall prevalence of PAS of 0.16%, and 31 studies were included in the meta-analysis. Prior non-cesarean uterine surgeries were associated with PAS in subsequent pregnancy (pooled OR 2.29, 95% CI, 1.43-3.68). Distinct associations between specific uterine surgery and PAS included myomectomy (OR 2.29, 95% CI, 1.77-2.97), uterine artery embolization (OR 43.16, 95% CI, 20.50-90.88), dilatation and curettage (OR 2.28, 95% CI, 1.78-2.93), hysteroscopic adhesiolysis (OR 7.72, 95% CI, 4.10-14.53), abortion (OR 1.65, 95% CI, 1.43-1.92), endometrial ablation (OR 20.26, 95% CI, 17.15-23.93), and operative hysteroscopy (OR 3.10, 95% CI, 1.86-5.18).

conclusionPrior non-cesarean uterine surgery is associated with a significantly increased odds for development of PAS in subsequent pregnancy, and the risk varies depending on the types of uterine surgery. SYSTEMATIC REVIEW REGISTRATION: PROSPERO: CRD42024552210.

Indexed as

Placenta AccretaUterusDilatation and CurettageFemaleHumansHysteroscopyPregnancyRisk FactorsUterine Artery EmbolizationUterine Myomectomy

Identifiers

PMID39913920
PMCPMC12068551

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.