Evidence map›Paper›PMID 39913579›Full record

ArticleScience (New York, N.Y.)2025

The essential genome of

Brendan Elsworth, Sida Ye, Sheena Dass, Jacob A Tennessen, Qudseen Sultana, Basil T Thommen, Aditya S Paul, Usheer Kanjee, Christof Grüring, Marcelo U Ferreira and 3 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. The essential function of the apical polar ring during the blood stage ofbioRxiv : the preprint server for biology · 2026
    Article
  14. International journal of molecular sciences · 2025
    Article
  15. Genetic analysis of pyrimidine biosynthetic enzymes inbioRxiv : the preprint server for biology · 2025
    Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Brendan Elsworth *Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-7025-7835
Sida Ye *Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-7206-1502
Sheena Dass *Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0001-7694-8867
Jacob A TennessenDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-5015-4740
Qudseen SultanaCenter for Personalized Cancer Therapy, University of Massachusetts Boston, Boston, MA, USA.
Basil T ThommenDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0001-7655-2440
Aditya S PaulDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0003-4123-7410
Usheer KanjeeDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-3169-4557
Christof GrüringDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Marcelo U FerreiraDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-5293-9090
Marc-Jan GubbelsDepartment of Biology, Boston College, Chestnut Hill, MA, USA.ORCID 0000-0002-2769-8600
Kourosh ZarringhalamDepartment of Mathematics, University of Massachusetts Boston, Boston, MA, USA.ORCID 0000-0002-5108-8108
Manoj T DuraisinghDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0001-8534-5515

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Comparative systems biology of apicomplexan cell divisionR01AI167570 · NIAID · BOSTON COLLEGE · PI Manoj T Duraisingh, Marc-Jan Gubbels · 2022 to 2026
$6.5M
Molecular basis of antimalarial drug resistance in Plasmodium vivaxR01AI168163 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Manoj T Duraisingh · 2022 to 2026
$3.9M
NIAID NIH HHS R01 AI167570NIAID NIH HHS R01 AI168163NIH HHS P51 OD011132
6 · The paper itself

Abstract

Measures to combat the parasites that cause malaria have become compromised because of reliance on a small arsenal of drugs and emerging drug resistance. We conducted a transposon mutagenesis screen in the primate malaria parasite

Indexed as

AntimalarialsArtemisininsDrug ResistanceGenes, EssentialGenetic FitnessGenome, ProtozoanPlasmodium knowlesiAnimalsDNA Transposable ElementsGenes, ProtozoanHumansMalariaMitochondriaMutagenesis, InsertionalAntimalarialsartemisininArtemisininsDNA Transposable Elements

Identifiers

PMID39913579
PMCPMC12104972

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.