Evidence map›Paper›PMID 39913207›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Extrinsic induction of apoptosis and tumor suppression via the p53-Reprimo-Hippo-YAP/TAZ-p73 pathway.

Masahiro Takikawa, Airi Nakano, Jayaraman Krishnaraj, Yuko Tabata, Yuzo Watanabe, Atsushi Okabe, Yukiko Sakaguchi, Ryoji Fujiki, Ami Mochizuki, Tomoko Tajima and 8 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. FAT4 loss promotes tumor growth and ferroptosis resistance in hepatocellular carcinoma via PI3K/AKT pathway activation.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  2. [Gastrodin alleviates hypobaric hypoxia-induced brain injury in rats by reducing neuronal ferroptosisNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Extrinsic induction of apoptosis and tumor suppression via the p53-Reprimo-Hippo-YAP/TAZ-p73 pathway.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Masahiro TakikawaLaboratory of Fundamental Oncology, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.ORCID 0009-0003-2261-7992
Airi NakanoLaboratory of Fundamental Oncology, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.ORCID 0009-0001-7372-6369
Jayaraman KrishnarajLaboratory of Fundamental Oncology, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.ORCID 0000-0002-0116-0546
Yuko TabataLaboratory of Fundamental Oncology, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.
Yuzo WatanabeProteomics Facility, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.
Atsushi OkabeDepartment of Molecular Oncology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan.ORCID 0000-0001-7748-6078
Yukiko SakaguchiLaboratory of Fundamental Oncology, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.
Ryoji FujikiDepartment of Molecular Oncology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan.
Ami MochizukiLaboratory of Fundamental Oncology, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.
Tomoko TajimaLaboratory of Fundamental Oncology, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.
Akane SadaLaboratory of Fundamental Oncology, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.
Shu MatsushitaLaboratory of Fundamental Oncology, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.
Yuichi WakabayashiCancer Genome Center, Division of Experimental Animal Research, Chiba Cancer Center Research Institute, Chuo-ku, Chiba 260-8717, Japan.
Kimi ArakiDivision of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan.
Atsushi KanedaDepartment of Molecular Oncology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan.ORCID 0000-0002-6980-5515
Fuyuki IshikawaDepartment of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Mahito SadaieDepartment of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan.ORCID 0000-0002-3443-5980
Rieko OhkiLaboratory of Fundamental Oncology, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.ORCID 0000-0002-7775-6653

Funding

Japan Agency for Medical Research and Development (AMED) P-Direct P-Create P-PromoteMinistry of Education, Culture, Sports, Science and Technology (MEXT) 19K16789 22K15548Ministry of Education, Culture, Sports, Science and Technology (MEXT) 20H03523 23K18382
6 · The paper itself

Abstract

Tumor progression is suppressed by inherent cellular mechanisms such as apoptosis. The

Indexed as

Adaptor Proteins, Signal TransducingApoptosisProtein Serine-Threonine KinasesTumor Suppressor Protein p53AnimalsCell Cycle ProteinsCell Line, TumorDNA-Binding ProteinsHippo Signaling PathwayHumansMiceNeoplasmsNuclear ProteinsPhosphoproteinsSignal TransductionTrans-ActivatorsAdaptor Proteins, Signal TransducingCell Cycle ProteinsDNA-Binding ProteinsNuclear ProteinsPhosphoproteinsProtein Serine-Threonine KinasesTP53 protein, humanTP73 protein, humanTrans-ActivatorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTranscription FactorsTumor Protein p73Tumor Suppressor Protein p53Tumor Suppressor ProteinsWWTR1 protein, humanYAP1 protein, humanYAP-Signaling ProteinsapoptosiscancerHippo pathwayp53p73

Identifiers

PMID39913207
PMCPMC11831151

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.