ReviewAnimal models and experimental medicine2025
Glaucoma animal models in rabbits: State of the art and perspectives-A review.
Review in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Long-Term Intraocular Pressure-Lowering and Antifibrotic Effects of a Biodegradable HA-Mg Glaucoma Drainage Implant in a Chronic Glaucoma Rabbit Model.Translational vision science & technology · 2026Article
- Evaluation of the iFalconBMC veterinary research · 2026Article
- Validation of eye occluding device developed from bottle caps for dopamine studies in rabbits: A pilot study.Open veterinary journal · 2026Article
- Experimental models to study oxidative stress in glaucoma: integratingFrontiers in pharmacology · 2026Review
- A Novel Rabbit Model of Angle-Closure Glaucoma Via Ciliary Block and Elevated Trans-Lens Pressure Difference.Investigative ophthalmology & visual science · 2025Article
- Molecular and Histological Characterization of a Novel Hydrogel-Based Strategy for Inducing Experimental Glaucoma in Mice.International journal of molecular sciences · 2025Article
- Evaluating the potential of travoprost-thymoquinone co-loaded liposomes: a glaucomatous rabbit model study.Therapeutic delivery · 2025Article
- Glaucoma animal models in rabbits: State of the art and perspectives-A review.Animal models and experimental medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Glaucoma, a visual thief, is characterized by elevated intraocular pressure (IOP) and the loss of retinal ganglion cells (RGCs). Selecting suitable animals for preclinical models is of great significance in research on the prevention, early screening, and effective treatments of glaucoma. Rabbit eyeballs possess similar vascularity and aqueous humor outflow pathways to those of humans. Thus, they are among the earliest in vivo models used in glaucoma research. Over the years, rabbit models have made substantial contributions to understanding glaucomatous pathophysiology, surgical adaptations, biomedical device development, and drug development for reducing IOP, protecting RGCs, and inhibiting fibrosis. Compared to other animals, rabbits fit better with surgical operations and cost less. This review summarizes the merits and demerits of different ways to produce glaucomatous rabbit models, such as intracameral injection, vortex vein obstruction, Trendelenburg position, laser photo-coagulation, glucocorticoid induction, limbal buckling induction, retinal ischemia-reperfusion models, and spontaneous models. We analyzed their mechanisms in the hope of providing more references for experimental design and promoting the understanding of glaucoma treatment strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.