Evidence map›Paper›PMID 39912977›Full record

ArticleIrish journal of medical science2025

Cost analysis of limb salvage: comparing limb revascularisation and amputation in patients with Chronic Limb-Threatening Ischaemia (CLTI) at University Hospital Limerick.

Anne Marie Toomey, Fiona Leahy, Helen Purtill, Norma O'Brien, Emer O'Donovan, Zeeshan Ahmed, Mekki Medani, Tony Moloney, Eamon G Kavanagh

Abstract readComparative Study
In one paragraph

Article in Irish journal of medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anne Marie ToomeySchool of Medicine, University of Limerick, Co. Limerick, V94 T9PX, Limerick, Ireland. annemarie.toomey1@gmail.com.ORCID http://orcid.org/0009-0004-4363-8642
Fiona LeahyDepartment of Vascular Surgery, University Hospital Limerick, St Nessan's Rd, V94 F858, Dooradoyle Co. Limerick, Ireland.
Helen PurtillSchool of Medicine, University of Limerick, Co. Limerick, V94 T9PX, Limerick, Ireland.
Norma O'BrienDepartment of Blood Transfusion, University Hospital Limerick, St Nessan's Rd, V94 F858, Dooradoyle, Co. Limerick, Ireland.
Emer O'DonovanDepartment of Blood Transfusion, University Hospital Limerick, St Nessan's Rd, V94 F858, Dooradoyle, Co. Limerick, Ireland.
Zeeshan AhmedDepartment of Vascular Surgery, University Hospital Limerick, St Nessan's Rd, V94 F858, Dooradoyle Co. Limerick, Ireland.
Mekki MedaniDepartment of Vascular Surgery, University Hospital Limerick, St Nessan's Rd, V94 F858, Dooradoyle Co. Limerick, Ireland.
Tony MoloneyDepartment of Vascular Surgery, University Hospital Limerick, St Nessan's Rd, V94 F858, Dooradoyle Co. Limerick, Ireland.
Eamon G KavanaghSchool of Medicine, University of Limerick, Co. Limerick, V94 T9PX, Limerick, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence of peripheral arterial disease (PAD) is increasing globally. An increase in PAD in an ageing population inevitably results in an increase in incidence of Chronic Limb Threatening Ischemia (CLTI). Loss of a limb is a life-changing event with immeasurable cost to the individual, while the potential financial benefit of saving a limb is not well documented.

aimsThe focus of this study was to estimate the cost associated with surgical interventions used in the treatment of CLTI compared with amputation.

methodsThe cost to treat a CLTI diagnosis in 124 patients was analysed in an acute tertiary referral hospital over a 13-month study period. The analysis included staffing, medical devices used, number of blood components used and the length of stay. Statistical methods included descriptive statistical data and the Mann-Whitney U test.

resultsThe median cost, associated with length of stay, post-amputation and post-revascularisation (hybrid) was €61,313 [IQR = €44,417, €83,331] and €46,573 [IQR = €25,687, €58,554] respectively, p < 0.001. The total median cost for length of stay for amputees in an acute hospital, rehabilitation and a prosthetic limb was €88,820 [IQR = €74,486, €110,248]. The median surgical cost of an amputation was €2,064 [IQR = €1,342, €2,866], whilst the median surgical cost of a revascularisation procedure (hybrid) was €5,966 [IQR = €4,380, €7,723], p < 0.001, inclusive of total blood components transfused.

conclusionRevascularisation surgical interventions are more expensive than amputation, however, the length of stay, rehabilitation and prosthetic limb costs, for a patient undergoing a major limb amputation, is significantly more costly.

Indexed as

Amputation, SurgicalChronic Limb-Threatening IschemiaIschemiaLimb SalvagePeripheral Arterial DiseaseVascular Surgical ProceduresAgedAged, 80 and overChronic DiseaseCosts and Cost AnalysisFemaleHospitals, UniversityHumansIrelandLength of StayMaleAmputationChronic limb threatening ischemiaCost analysisLength of stayRevascularisationVascular procedures

Identifiers

PMID39912977
PMCPMC12031980

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.