Relevant markers for overactive bladder laser therapy: nitric oxide and urinary nerve growth factor.

Rasha Ahmed, Omnia Hamdy, Mona Mohamed Abdulwehab, Ibrahim Abdel-Halim, Amany Ahmed Soliman, Shaimaa Elattar

Abstract readRandomized Controlled Trial

In one paragraph

Trial report in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rasha AhmedUrology Department, Faculty of Medicine for Girls, Al Azhar University, Cairo, Egypt.

Omnia HamdyEngineering Applications of Lasers Department, National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt. omnia@niles.edu.eg.ORCID http://orcid.org/0000-0002-8662-1451

Mona Mohamed AbdulwehabClinical Pathology Department, Faculty of Medicine for Girls, Al Azhar University, Giza, Egypt.

Ibrahim Abdel-HalimEngineering Applications of Lasers Department, National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt.

Amany Ahmed SolimanUrology Department, Faculty of Medicine for Girls, Al Azhar University, Cairo, Egypt.

Shaimaa ElattarClinical Pathology Department, Faculty of Medicine for Girls, Al Azhar University, Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the potential of nitric oxide (NO) and urinary nerve growth factor (NGF) as indicators of therapeutic outcomes in overactive bladder (OAB) patients undergoing low-level laser therapy (LLLT) via a prospective randomized controlled trial. Fifty OAB patients participated in the study and were subjected to LLLT using 650-nm laser irradiation. The study employed a prospective randomized controlled trial design. Nitric oxide and urine NGF levels were assessed before and after the LLLT intervention to evaluate their correlation with therapeutic outcomes. The study provided evidence supporting the effectiveness of LLLT as a treatment modality for OAB. Analysis of NO and urine NGF levels revealed significant changes following LLLT intervention suggesting their potential as biomarkers for assessing therapeutic response in OAB patients. These biomarkers hold promise for aiding clinicians in evaluating treatment response and personalizing therapy approaches for OAB patients. This study highlights the utility of LLLT in managing OAB and underscores the importance of exploring biomarkers such as nitric oxide and urinary nerve growth factor to enhance treatment efficacy assessment. The findings suggest that NO and urine NGF levels may serve as valuable indicators of therapeutic outcomes in OAB patients undergoing LLLT. Further research is warranted to elucidate the underlying mechanisms and optimize the clinical application of LLLT in OAB management.

Indexed as

Low-Level Light TherapyNerve Growth FactorNitric OxideUrinary Bladder, OveractiveAdultAgedBiomarkersFemaleHumansMaleMiddle AgedProspective StudiesTreatment OutcomeBiomarkersNerve Growth FactorNGF protein, humanNitric OxideLow-level lasersNitric oxideOveractive bladderPhotobiomodulationUrinary nerve growth factor

Identifiers

PMID39912973

DOI10.1016/j.purol.2013.07.005

PMCPMC11802713

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.