Evidence map›Paper›PMID 39912781›Full record

ArticleAdvanced biology2025

Herbal Formula Yi-Fei-Jie-Du-Tang Regulates Epithelial-Mesenchymal Transition and Vasculogenic Mimicry in Lung Cancer via HIF1A-Mediated Ferroptosis.

Shanshan Wang, Die Yang, Chengjia Yuan, Yang Wu, Qingying Wang, Yongjian Wu, Xiaochun Zhang

Abstract read
In one paragraph

Article in Advanced biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shanshan WangDepartment of Oncology, Yangzhou Hospital of Traditional Chinese Medicine, Yangzhou, Jiangsu, 225002, China.ORCID https://orcid.org/0000-0001-5195-1955
Die YangDepartment of Oncology, Yangzhou Hospital of Traditional Chinese Medicine, Yangzhou, Jiangsu, 225002, China.
Chengjia YuanClinical Traditional Chinese Medical College, Yangzhou University, Yangzhou, Jiangsu, 225002, China.
Yang WuClinical Traditional Chinese Medical College, Yangzhou University, Yangzhou, Jiangsu, 225002, China.
Qingying WangDepartment of Oncology, Yangzhou Hospital of Traditional Chinese Medicine, Yangzhou, Jiangsu, 225002, China.
Yongjian WuDepartment of Oncology, Yangzhou Hospital of Traditional Chinese Medicine, Yangzhou, Jiangsu, 225002, China.
Xiaochun ZhangDepartment of Oncology, Yangzhou Hospital of Traditional Chinese Medicine, Yangzhou, Jiangsu, 225002, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditional Chinese medicine (TCM) Yi-Fei-Jie-Du-Tang (YFJDT) has shown potential in lung cancer treatment. However, the mechanisms underlying the effects of YFJDT on lung cancer remain unclear. Bioinformatics analysis is conducted to identify potential targets of YFJDT. The impact of YFJDT on hypoxia-inducible factor 1 alpha (HIF1A), ferroptosis, and vasculogenic mimicry (VM) is investigated using xenograft tumor models and A549 cells. Additionally, A549 cells are stimulated with CoCl

Indexed as

Drugs, Chinese HerbalEpithelial-Mesenchymal TransitionFerroptosisHypoxia-Inducible Factor 1, alpha SubunitLung NeoplasmsNeovascularization, PathologicA549 CellsAnimalsCell Line, TumorHumansMiceMice, Inbred BALB CMice, NudeXenograft Model Antitumor AssaysDrugs, Chinese HerbalHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitcancerEMTferroptosishypoxia‐inducible factorTCMvasculogenic mimicry

Identifiers

PMID39912781
PMCPMC11911945

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.