Evidence map›Paper›PMID 39912749›Full record

Trial reportAIDS (London, England)2025

Sociobehavioral determinants of nonretention among adolescents and young adults with HIV.

Sarah Hicks, Wenwen Jiang, James Kibugi, Jacinta Badia, Barbra A Richardson, Kristin Beima-Sofie, Kawango Agot, Pamela Kohler, Grace John-Stewart

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05007717 (Data-informed Stepped Care), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05007717 nacompletednot on this map

Data-informed Stepped Care (DiSC) to Improve Adolescent HIV Outcomes (UH3)

TypeinterventionalSponsorUniversity of WashingtonRan2022 to 2023Enrolled1,911ConditionsAdolescent Behavior, HivArmsData-informed Stepped Care (DiSC)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sarah HicksDepartment of Epidemiology.
Wenwen JiangDepartment of Global Health, University of Washington, Seattle, WA, USA.
James KibugiImpact Research & Development Organization, Kisumu, Kenya.
Jacinta BadiaImpact Research & Development Organization, Kisumu, Kenya.
Barbra A RichardsonDepartment of Global Health, University of Washington, Seattle, WA, USA.
Kristin Beima-SofieDepartment of Global Health, University of Washington, Seattle, WA, USA.
Kawango AgotImpact Research & Development Organization, Kisumu, Kenya.
Pamela KohlerDepartment of Global Health, University of Washington, Seattle, WA, USA.
Grace John-StewartDepartment of Epidemiology.

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
Data-informed Stepped Care (DiSC) to Improve Adolescent HIV OutcomesUH3HD096906 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C., KOHLER, PAMELA · 2020 to 2022
$3.1M
Data-informed Stepped Care (DiSC) to Improve Adolescent HIV OutcomesUG3HD096906 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C., KOHLER, PAMELA · 2018 to 2019
$1.9M
Effects of caregiver interactions, youth characteristics, and counseling on retention in care among youth living with HIVF31HD116617 · NICHD · UNIVERSITY OF WASHINGTON · PI HICKS, SARAH · 2024 to 2024
$49k
NIAID NIH HHS P30 AI027757NICHD NIH HHS F31 HD116617NICHD NIH HHS UG3 HD096906NICHD NIH HHS UH3 HD096906
6 · The paper itself

Abstract

objectiveThis study aimed to identify age-specific cofactors of nonretention among adolescents and young adults with HIV (AYHIV) ages 10-24.

designThis analysis used data from the Data-Informed Stepped Care study (DiSC; NCT05007717), a cluster randomized clinical trial in 24 health facilities in Western Kenya.

methodsDuring 12-month follow-up, youth-reported cofactors of missed visits and loss-to-follow-up (LTFU; did not return to clinic within study period) were assessed using generalized linear and mixed effect models and stratified by gender and age.

resultsAmong 1904 AYHIV, median age was 17 years (interquartile range 14-19), and 57.9% were female. A higher proportion of missed visits was observed in older ages (10-14: 6.0%; 15-19: 7.9%; 20-24: 12.5%). Overall, higher resilience (prevalence ratio (PR) = 0.93) and satisfaction with clinic (PR = 0.81) were associated with lower risk of missed visits. Among males, satisfaction with clinic was associated with lower risk (PR = 0.61) while higher stigma was associated with increased risk (PR = 1.31). Among females, resilience was associated with lower risk (PR = 0.93). Having no living parents was associated with higher LTFU risk (PR = 2.24). Among males, horizontal transmission was associated with higher risk (PR = 2.98) and resilience with lower risk (PR = 0.76). Females who came to clinic alone had lower risk of LTFU (PR = 0.27). Age-stratified analyses did not identify additional cofactors.

conclusionsIn this large multisite cohort, older AYHIV had the most retention challenges. Resilience, satisfaction with clinical care, and stigma exerted an influential role, but cofactors differed between age and gender strata, underscoring the heterogeneity of AYHIV and suggesting need for tailored approaches.

Indexed as

HIV InfectionsLost to Follow-UpAdolescentAge FactorsChildFemaleHumansKenyaMaleYoung AdultadolescentHIVpatient satisfactionpsychologicalresilienceretention in caresocial stigmayoung adult

Identifiers

PMID39912749
PMCPMC12064368

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.