Evidence map›Paper›PMID 39912665›Full record

ArticleJournal of virology2025

Contrasting roles of PSGL-1 and PD-1 in regulating T-cell exhaustion and function during chronic viral infection.

Karla M Viramontes, Melissa N Thone, Jamie-Jean De La Torre, Emily N Neubert, Julia M DeRogatis, Chris Garcia, Monique L Henriquez, Roberto Tinoco

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Adoptive T-cell therapies in the clinic.Bioengineering & translational medicine · 2026
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Karla M Viramontes *Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, California, USA.
Melissa N Thone *Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, California, USA.
Jamie-Jean De La TorreDepartment of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, California, USA.
Emily N NeubertDepartment of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, California, USA.
Julia M DeRogatisDepartment of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, California, USA.
Chris GarciaDepartment of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, California, USA.
Monique L HenriquezDepartment of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, California, USA.
Roberto TinocoDepartment of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California Irvine, Irvine, California, USA.ORCID 0000-0001-5420-9692

Funding

MINORITY BIOMEDICAL RESEARCHERS PROGRAMR25GM055246 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI MOTA-BRAVO, LUIS M · 1996 to 2022
$15.3M
CARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6M
UCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSEN, BOGI, GANESAN, ANAND K · 2019 to 2025
$5.1M
Virus-host interactions: a multi-scale training programT32AI007319 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI SEMLER, BERT L, SHI, YONGSHENG · 1988 to 2024
$2.4M
PSGL-1 mechanisms of T cell exhaustionR01AI137239 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI TINOCO, ROBERTO · 2019 to 2024
$2.1M
T32 for Training in Microbiology & Infectious DiseasesT32AI141346 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Celia Goulding, Melissa Bruckner Lodoen · 2019 to 2026
$1.0M
Interdisciplinary Training Program in Skin BiologyT32AR080622 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Bogi Andersen, Anand K Ganesan · 2022 to 2026
$909k
HHS | National Institutes of Health (NIH) AI137239HHS | National Institutes of Health (NIH) T32AI141346HHS | National Institutes of Health (NIH) T32AR080622HHS | National Institutes of Health (NIH) T32CA009054National Institutes of Health (NIH) T32AI007319NCI NIH HHS T32 CA009054NIAID NIH HHS R01 AI137239NIAID NIH HHS T32 AI007319NIAID NIH HHS T32 AI141346NIAMS NIH HHS P30 AR075047NIAMS NIH HHS T32 AR080622NIGMS NIH HHS R25 GM055246
6 · The paper itself

Abstract

Immune checkpoints are critical regulators of T-cell exhaustion, impairing their ability to eliminate antigens present during chronic viral infections. Current immune checkpoint inhibitors (ICIs) used in the clinic aim to reinvigorate exhausted T cells; yet, most patients fail to respond or develop resistance to these therapies, underscoring the need to better understand these immunosuppressive pathways. PSGL-1 (

Indexed as

CD8-Positive T-LymphocytesLymphocytic ChoriomeningitisMembrane GlycoproteinsPersistent InfectionProgrammed Cell Death 1 ReceptorAnimalsChronic DiseaseLymphocytic choriomeningitis virusMiceMice, Inbred C57BLMice, KnockoutT-Cell ExhaustionMembrane GlycoproteinsPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorP-selectin ligand proteinCD8 T cellimmune dysfunctionlymphocytic choriomeningitis virusT cellsviral immunity

Identifiers

PMID39912665
PMCPMC11915808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.